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Titolo:
Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning
Autore:
Rodrigues, SM; Schafe, GE; LeDoux, JE;
Indirizzi:
NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, New York, NY 10003 USA NYU New York NY USA 10003 Keck Fdn Lab Neurobiol, New York, NY 10003 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 17, volume: 21, anno: 2001,
pagine: 6889 - 6896
SICI:
0270-6474(20010901)21:17<6889:IBOTNS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; D-ASPARTATE RECEPTOR; PROTEIN-KINASE-II; GYRUS IN-VIVO; BASOLATERAL AMYGDALA; LATERAL AMYGDALA; SYNAPTIC TRANSMISSION; TYROSINE PHOSPHORYLATION; GLUTAMATE RECEPTORS; MEMORY FORMATION;
Keywords:
fear; learning; amygdala; NMDA receptor; NR2B subunit; ifenprodil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: LeDoux, JE NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, 4 Washington Pl,Room 809, New York, NY 10003 USA NYU 4 Washington Pl,Room 809 New York NY USA 10003 NY 10003 USA
Citazione:
S.M. Rodrigues et al., "Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning", J NEUROSC, 21(17), 2001, pp. 6889-6896

Abstract

The lateral nucleus of the amygdala (LA) is an essential component of the neural circuitry underlying Pavlovian fear conditioning. Although blockade of NMDA receptors in LA and adjacent areas before training disrupts the acquisition of fear conditioning, blockade before testing also often disrupts the expression of fear responses. With this pattern of results, it is not possible to distinguish a contribution of NMDA receptors to plasticity from a role in synaptic transmission. In past studies, NMDA blockade has been achieved using the antagonist D, L-2-amino-5-phosphovalerate, which blocks the entire heteromeric receptor complex. The present experiments examined theeffects of selective blockade of the NR2B subunit of the NMDA receptor in LA using the selective antagonist ifenprodil. Systemic injections of ifenprodil before training led to a dose-dependent impairment in the acquisition of auditory and contextual fear conditioning, whereas injections before testing had no effect. Intra-amygdala infusions of ifenprodil mirrored these results and, in addition, showed that the effects are attributable to a disruption of fear learning rather than a disruption of memory consolidation. NMDA receptors in LA are thus involved in fear conditioning, and the NR2B subunit appears to make unique contributions to the underlying plasticity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 04:35:59