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Titolo:
Pharmacological modulation of behavioral and neuronal correlates of repetition priming
Autore:
Thiel, CM; Henson, RNA; Morris, JS; Friston, KJ; Dolan, RJ;
Indirizzi:
Inst Neurol, Wellcome Dept Cognit Neurol, London WC1 3BG, England Inst Neurol London England WC1 3BG ognit Neurol, London WC1 3BG, England Univ Coll London, Inst Cognit Neurosci, London WC1 3BG, England Univ Coll London London England WC1 3BG eurosci, London WC1 3BG, England Royal Free Hosp, Sch Med, London NW3 2PF, England Royal Free Hosp LondonEngland NW3 2PF Sch Med, London NW3 2PF, England
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 17, volume: 21, anno: 2001,
pagine: 6846 - 6852
SICI:
0270-6474(20010901)21:17<6846:PMOBAN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; INFERIOR PREFRONTAL CORTEX; EXPLICIT MEMORY; HEALTHY-VOLUNTEERS; TEMPORAL CORTEX; FUNCTIONAL MRI; SCOPOLAMINE; LORAZEPAM; DIAZEPAM; HUMANS;
Keywords:
fMRI; priming; scopolamine; lorazepam; psycho-pharmacology; neuroimaging; word-stem completion; repetition suppression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Thiel, CM Inst Neurol, Wellcome Dept Cognit Neurol, 12 Queen Sq, London WC1 3BG, England Inst Neurol 12 Queen Sq London England WC1 3BG WC1 3BG, England
Citazione:
C.M. Thiel et al., "Pharmacological modulation of behavioral and neuronal correlates of repetition priming", J NEUROSC, 21(17), 2001, pp. 6846-6852

Abstract

In this experiment we address the pharmacological modulation of repetitionpriming, a basic form of learning, using event-related functional magneticresonance imaging. We measured brain activity in a word-stem completion paradigm in which, before study, volunteers were given either placebo, lorazepam (2 mg orally), or scopolamine (0.4 mg, i.v.). Relative to placebo, bothdrugs attenuated the behavioral expression of priming. Repetition was associated with a decreased neuronal response in left extrastriate, left middlefrontal, and left inferior frontal cortices in the placebo group. Both drugs abolished these "repetition suppression" effects. By showing a concurrence of behavioral and neuronal modulations, the results suggest that GABAergic and cholinergic systems influence the neuronal plasticity necessary for repetition priming.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:42:35