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Titolo:
Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex
Autore:
Rozas, C; Frank, H; Heynen, AJ; Morales, B; Bear, MF; Kirkwood, A;
Indirizzi:
Johns Hopkins Univ, Mind Brain Inst, Baltimore, MD 21218 USA Johns HopkinsUniv Baltimore MD USA 21218 n Inst, Baltimore, MD 21218 USA Brown Univ, Howard Hughes Med Inst, Dept Neurosci, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 ept Neurosci, Providence, RI 02912 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 17, volume: 21, anno: 2001,
pagine: 6791 - 6801
SICI:
0270-6474(20010901)21:17<6791:DIGCTR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; SOURCE DENSITY ANALYSIS; MONOCULAR DEPRIVATION; RAT NEOCORTEX; SYNAPTIC DEPRESSION; EVOKED-POTENTIALS; PYRAMIDAL NEURONS; IN-VITRO; POSTNATAL-DEVELOPMENT; LAMINAR DISTRIBUTION;
Keywords:
critical period; plasticity; GABA; paired-pulse depression; neocortex; layer IV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Kirkwood, A Johns Hopkins Univ, Mind Brain Inst, 338 Krieger Hall,3400 N Charles St, Baltimore, MD 21218 USA Johns Hopkins Univ 338 Krieger Hall,3400N Charles St Baltimore MD USA 21218
Citazione:
C. Rozas et al., "Developmental inhibitory gate controls the relay of activity to the superficial layers of the visual cortex", J NEUROSC, 21(17), 2001, pp. 6791-6801

Abstract

A developmental reduction in the radial transmission of synaptic activity has been proposed to underlie the end of the critical period for experience-dependent modification in layers II/III of the visual cortex. Using paired-pulse stimulation, we investigated in visual cortical slices how the propagation of synaptic activity to the superficial layers changes during development and how this process is affected by sensory experience. The results can be summarized as follows. (1) Layers II/III responses to repetitive stimulation of the white matter become increasingly depressed between the thirdand sixth week of postnatal development, a time course that parallels the end of the critical period. (2) Paired-pulse depression is reduced after dark rearing and also by blocking inhibitory synaptic transmission. (3) Paired-pulse depression and its regulation by age and sensory experience is morepronounced when stimulation is applied to the white matter than when applied to layer IV. Together, these results are consistent with the idea that the maturation of intracortical inhibition reduces the capability of the cortex to relay incoming high-frequency patterns of activity to the supragranular layers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:36:35