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Titolo:
Thyroid hormone regulates oxidative phosphorylation in the cerebral cortexand striatum of neonatal rats
Autore:
Martinez, B; del Hoyo, P; Martin, MA; Arenas, J; Perez-Castillo, A; Santos, A;
Indirizzi:
Univ Complutense Madrid, Fac Med, Dept Bioquim & Biol Mol 3, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 ol 3, E-28040 Madrid, Spain Hosp Doce Octubre, Ctr Invest, Madrid, Spain Hosp Doce Octubre Madrid Spain Doce Octubre, Ctr Invest, Madrid, Spain CSIC, Inst Invest Biomed, Madrid, Spain CSIC Madrid SpainCSIC, Inst Invest Biomed, Madrid, Spain
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 5, volume: 78, anno: 2001,
pagine: 1054 - 1063
SICI:
0022-3042(200109)78:5<1054:THROPI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL TRANSCRIPTION FACTOR; ELECTRON-TRANSPORT CHAIN; A GENE-EXPRESSION; BRAIN-DEVELOPMENT; POSTNATAL-DEVELOPMENT; LIVER-MITOCHONDRIA; NUCLEAR RECEPTORS; SYNAPTIC MITOCHONDRIA; OXYGEN-CONSUMPTION; RNA-SYNTHESIS;
Keywords:
brain; development; gene expression; mitochondria; oxidative phosphorylation; thyroid hormone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Perez-Castillo, A Univ Complutense Madrid, Fac Med, Dept Bioquim & Biol Mol 3, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 id, Spain
Citazione:
B. Martinez et al., "Thyroid hormone regulates oxidative phosphorylation in the cerebral cortexand striatum of neonatal rats", J NEUROCHEM, 78(5), 2001, pp. 1054-1063

Abstract

We have previously shown that thyroid hormone (T-3) regulates mitochondrial gene expression, morphology and transmembrane potential in the developingbrain. Here, we have analysed the effect of thyroid hormone on mitochondrial function in different brain regions. For this purpose we have determined, in control, hypothyroid and T-3-treated hypothyroid neonatal rats, the rate of oxidative phosphorylation in isolated mitochondria and the activity of the respiratory complexes in tissue homogenates. Our results showed a decrease in oxidative phosphorylation rate (only in the presence of NADH-generating substrates) and mitochondrial complexes I and III activity in the cerebral cortex and striatum of hypothyroid neonates, but not in the other areas analysed (hippocampus, cerebellum, thalamus, mid brain and brain stem). In parallel with mitochondrial activity, the levels of mitochondrially encoded transcripts were decreased only in the cerebral cortex and striatum of hypothyroid rats. The administration of T-3 corrected all these parameters. In summary, this study showed a down-regulation of mitochondrial gene expression accompanied by a decrease in mitochondrial activity in the cerebral cortex and striatum of developing hypothyroid neonatal rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:38:10