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Titolo:
Structural studies on conformationally defined 6-s-trans UAB retinoids
Autore:
Ponder, MS; Long, JA; Williams, LM; Hamilton, TP; Muccio, DD;
Indirizzi:
Samford Univ, Dept Chem, Birmingham, AL 35229 USA Samford Univ BirminghamAL USA 35229 Dept Chem, Birmingham, AL 35229 USA Univ Alabama, Dept Chem, Birmingham, AL 35294 USA Univ Alabama BirminghamAL USA 35294 Dept Chem, Birmingham, AL 35294 USA
Titolo Testata:
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
, volume: 549, anno: 2001,
pagine: 39 - 45
SICI:
0166-1280(20010806)549:<39:SSOCD6>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-ORBITAL METHODS; NUCLEAR RECEPTOR-BINDING; ACID ANALOGS; TRANSCRIPTIONAL ACTIVITY; CHEMOPREVENTIVE ACTIVITY; CRYSTAL-STRUCTURE; BASIS-SETS; AB-INITIO; CHROMOPHORE; SPECTRUM;
Keywords:
retinoids; conformational analysis; steric interaction; molecular geometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Ponder, MS Samford Univ, Dept Chem, Birmingham, AL 35229 USA Samford UnivBirmingham AL USA 35229 Birmingham, AL 35229 USA
Citazione:
M.S. Ponder et al., "Structural studies on conformationally defined 6-s-trans UAB retinoids", J MOL ST-TH, 549, 2001, pp. 39-45

Abstract

The calculated structures of ten conformationally defined 6-s-trans retinoids are reported here. These compounds are precursors and intermediates in the synthesis of biologically active derivatives of retinoic acid. Of particular interest are the ring geometries in these compounds because of their importance in the interaction of the derivatives with the binding site of the receptors. The ring conformation in these compounds depends primarily ontwo specific sites of steric interaction. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 00:12:59