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Titolo:
Circulation of enteroviruses and persistence of meningitis cases in the winter of 1999-2000
Autore:
Chambon, M; Archimbaud, C; Bailly, JL; Henquell, C; Regagnon, C; Charbonne, F; Peigue-Lafeuille, H;
Indirizzi:
CHRU, Fac Med, Virol Lab, F-63001 Clermont Ferrand, France CHRU Clermont Ferrand France F-63001 b, F-63001 Clermont Ferrand, France
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 2, volume: 65, anno: 2001,
pagine: 340 - 347
SICI:
0146-6615(200110)65:2<340:COEAPO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; CEREBROSPINAL-FLUID; ASEPTIC-MENINGITIS; ECHOVIRUS TYPE-30; VIRAL MENINGITIS; PCR ASSAY; DIAGNOSIS; SURVEILLANCE; INFECTIONS; SPECIMENS;
Keywords:
echovirus; coxsackievirus; epidemiology; RT-PCR; cerebrospinal fluid; adult;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Chambon, M CHRU, Fac Med, Virol Lab, 28 Pl Henri Dunant, F-63001 Clermont Ferrand, France CHRU 28 Pl Henri Dunant Clermont Ferrand France F-63001 France
Citazione:
M. Chambon et al., "Circulation of enteroviruses and persistence of meningitis cases in the winter of 1999-2000", J MED VIROL, 65(2), 2001, pp. 340-347

Abstract

The seasonal incidence of enterovirus meningitis was analyzed in a prospective study of patients admitted for suspected meningitis from October 1, 1998 to April 30, 2000. In-house reverse transcription-polymerase chain reaction (RT-PCR) in cerebrospinal fluid (CSF) was used irrespective of cytological results. Fifty-two (45.2%) of the 115 patients had positive RT-PCR in CSF, including 44/86 children (51.2%) and 8/29 adults (27.6%). Six of the 52(11.5%) had no pleocytosis. The numbers of CSF specimens with a predominance of lymphocytes or a predominance of neutrophils were closely similar. In33 of the positive patients, an enterovirus, mainly echoviruses type 6 (48%) and 30 (24%), was recovered in one or more specimens. Sixteen cases of enteroviral meningitis were observed between November 1999 and March 2000 asagainst 2 cases between November 1998 and March 1999, showing that the disease persisted through the winter months of 1999-2000. During the same period, 96 enterovirus isolates were recovered from clinical specimens from other patients. The number of isolates was higher in the winter of 1999-2000 (P <0.01) than in the winter of 1998-1999, indicating that the risk of enterovirus infection increased significantly in winter 1999-2000. Sixteen patients had aseptic meningitis, made a rapid recovery and had an enterovirus inthroat swabs and stools (9/16) or in one of the two (7/16). RT-PCR was notrequested. Nine patients were admitted during the cold months. The clinical management of both adult and child patients could be improved by year-round use of enterovirus generic RT-PCR. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:03:55