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Titolo:
Altered renal expression of aquaporin-2 water channels in rats with experimental two-kidney, one clip hypertension
Autore:
Lee, J; Oh, Y; Kim, SW;
Indirizzi:
Chonnam Natl Univ, Sch Med, Dept Physiol, Dong Gu, Kwangju 501746, South Korea Chonnam Natl Univ Kwangju South Korea 501746 Kwangju 501746, South Korea Chonnam Natl Univ, Sch Med, Res Inst Med Sci, Dong Gu, Kwangju 501746, South Korea Chonnam Natl Univ Kwangju South Korea 501746 Kwangju 501746, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 4, volume: 16, anno: 2001,
pagine: 462 - 466
SICI:
1011-8934(200108)16:4<462:AREOAW>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; VASOPRESSIN; MAINTENANCE; HYPOXIA; FAILURE;
Keywords:
two-kidney, one clip hypertension; aquaporins; adenylyl cyclase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, J Chonnam Natl Univ, Sch Med, Dept Physiol, Dong Gu, 5 Hak Dong, Kwangju 501746, South Korea Chonnam Natl Univ 5 Hak Dong Kwangju South Korea 501746 outh Korea
Citazione:
J. Lee et al., "Altered renal expression of aquaporin-2 water channels in rats with experimental two-kidney, one clip hypertension", J KOR MED S, 16(4), 2001, pp. 462-466

Abstract

The present study was aimed at examining the regulation of aquaporin (AQP)-2 water channels in the kidney in two-kidney, one clip (2K1C) hypertension. Rats were made 2K1C hypertensive for 6 weeks, and their expression of AQP2 channel proteins was determined in the clipped and contralateral kidneys. To examine the upstream affecting AQP2 channels, adenylyl cyclase activitywas also determined. Along with the hypertension, in the clipped kidney, the abundance of AQP2 proteins was significantly decreased in the cortex, outer and inner medulla, while their trafficking remained unaltered. Concomitantly with the reversal of the blood pressure at 24 hours following removalof the clip, the AQP2 abundance also returned to the control level. The arginine vasopressin-evoked generation of cAMP was decreased in the clipped kidney, which again was reversed to the control level following removal of the clip. In contrast, the expression of AQP2 channels as well as the activity of adenylyl cyclase remained unaltered in the contralateral kidney. These results indicate an altered regulation of AQP2 water channels in the clipped kidney in 2K1C hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:14:49