Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Does albumin preinfusion potentiate diuretic action of furosemide in patients with nephrotic syndrome?
Autore:
Na, KY; Han, JS; Kim, YS; Ahn, C; Kim, S; Lee, JS; Bae, KS; Jang, IJ; Shin, SG; Huh, W; Jeon, US;
Indirizzi:
Seoul Natl Univ, Dept Internal Med & Pharmacol, Seoul, South Korea Seoul Natl Univ Seoul South Korea l Med & Pharmacol, Seoul, South Korea Sungkyunkwan Univ, Dept Internal Med, Seoul, South Korea Sungkyunkwan Univ Seoul South Korea pt Internal Med, Seoul, South Korea Gyeongsang Natl Univ, Dept Internal Med, Chinju, South Korea Gyeongsang Natl Univ Chinju South Korea ternal Med, Chinju, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 4, volume: 16, anno: 2001,
pagine: 448 - 454
SICI:
1011-8934(200108)16:4<448:DAPPDA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-BINDING; RESISTANCE; PLASMA; VASOPRESSIN; DISPOSITION; FRUSEMIDE; MECHANISM; RATS;
Keywords:
albumin preinfusion; furosemide; diuresis; natriuresis; nephrotic syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Han, JS Seoul Natl Univ, Coll Med, Dept Internal Med, Chongno Gu, 28 Yongun Dong, Seoul 110744, South Korea Seoul Natl Univ 28 Yongun Dong Seoul South Korea 110744 uth Korea
Citazione:
K.Y. Na et al., "Does albumin preinfusion potentiate diuretic action of furosemide in patients with nephrotic syndrome?", J KOR MED S, 16(4), 2001, pp. 448-454

Abstract

The aim of this cross-over study was to investigate whether albumin infusion before furosemide administration could potentiate the diuretic action offurosemide. Seven patients with nephrotic syndrome were given the following infusions in random order on two separate days: 1) a sham solution followed by 160 mg of furosemide, 2) 100 mL of 20% human albumin followed by 160 mg of furosemide. Urine and serum furosemide concentrations were measured by high-performance liquid chromatography. The increment of urine volume wasgreater in albumin preinfusion than in furosemide alone. However, the increments of sodium and chloride excretions between furosemide alone and albumin preinfusion were not different. No significant differences in the pharmacokinetic parameters between the two treatments were observed: area under the concentration-time curve (AUC: 12.7 +/- 2.2 vs 15.1 +/- 4.4 mug/mL (.) hr), total plasma clearance (253 +/- 41 vs 256 +/- 54 mL/min), volume of distribution (341 +/- 34 vs 494 +/- 153 mL/kg), elimination half life (4.0 +/-1.1 vs 4.6 +/- 0.8 hr), and urine furosemide excretion of the administeredamount (16.5 +/- 7.3 vs 7.5 +/- 1.6%). In conclusion, these data show thatalbumin preinfusion potentiated diuresis, but not natriuresis, of furosemide without any change in the pharmacokinetics of the agent in patients withnephrotic syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:23:54