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Titolo:
Parenchymal and nonparenchymal cellular responses in human hepatic regeneration
Autore:
Yoon, GS; Suriawinata, A; Thung, SN; Yu, ES;
Indirizzi:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol,Songpa Gu, Seoul 138736, South Korea Univ Ulsan Seoul South Korea 138736 Songpa Gu, Seoul 138736, South Korea Mt Sinai Med Ctr, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA10029 ai Med Ctr, New York, NY 10029 USA
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 4, volume: 16, anno: 2001,
pagine: 439 - 447
SICI:
1011-8934(200108)16:4<439:PANCRI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LIVER-DISEASE; PROGENITOR CELLS; NUCLEAR ANTIGEN; GROWTH-FACTOR; ITO CELLS; NECROSIS; HEPATOCYTES; MACROPHAGES; FAILURE; IDENTIFICATION;
Keywords:
liver failure; hepatitis; liver regeneration; Kupffer cells; hepatic stellate cell; hepatic stem cells; bile ducts; epithelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yu, ES Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol,Songpa Gu, 388-1 Poongnap Dong, Seoul 138736, South Korea Univ Ulsan 388-1 Poongnap Dong Seoul South Korea 138736 outh Korea
Citazione:
G.S. Yoon et al., "Parenchymal and nonparenchymal cellular responses in human hepatic regeneration", J KOR MED S, 16(4), 2001, pp. 439-447

Abstract

To characterize cellular responses during hepatic regeneration, we examined 13 explant livers and 5 liver allografts by immunohistochemistry for cytokeratin 7, HepPar1, CD68, alpha -smooth muscle actin (alpha -SMA) and proliferating cell nuclear antigen as well as reticulin and Masson-trichrome staining. Within a week after liver damage, elongated CD68-positive cells weredetected along the border of necrotic area. The number of alpha -SMA-positive cells was slightly increased along the sinusoids. Ductular proliferation or fibrosis was negligible. After one or two weeks, the size and number of CD68-positive cells were markedly increased. alpha -SMA-positive cells increased in number within lobules and portal tracts. Ductular proliferation occurred predominantly at the limiting plate or along the border of necrotic areas. After one month, necrotic parenchyma was replaced by many ductules, CD68-positive cells, alpha -SMA-positive cells. Nodules of regenerating hepatocytes and irregular fibrosis were diffusely present. Other nonparenchymal cells were not significantly changed. These observations indicate that chronological interaction between nonparenchymal and parenchymal cells occur during the course of human hepatic regeneration and suggest extensive porto-periportal fibrosis more than a few months after the onset of fulminant hepatitis is a major indicator of chronic functional impairment necessitating liver transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:22:22