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Titolo:
Effect of high fat diet on insulin resistance: Dietary fat versus visceralfat mass
Autore:
Park, S; Kim, YW; Kim, JY; Jang, EC; Doh, KO; Lee, SK;
Indirizzi:
Yeungnam Univ, Coll Med, Dept Physiol, Nam Gu, Taegu 705717, South Korea Yeungnam Univ Taegu South Korea 705717 Nam Gu, Taegu 705717, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 4, volume: 16, anno: 2001,
pagine: 386 - 390
SICI:
1011-8934(200108)16:4<386:EOHFDO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE; ACID; RATS; SENSITIVITY; OBESITY; LIVER; MECHANISMS; METABOLISM; TISSUE; WOMEN;
Keywords:
dietary fats; glucose clamp technique; obesity; insulin resistance; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SK Yeungnam Univ, Coll Med, Dept Physiol, Nam Gu, 317-1 Daemyung 5 Dong, Taegu 705717, South Korea Yeungnam Univ 317-1 Daemyung 5 Dong Taegu South Korea 705717 orea
Citazione:
S. Park et al., "Effect of high fat diet on insulin resistance: Dietary fat versus visceralfat mass", J KOR MED S, 16(4), 2001, pp. 386-390

Abstract

The purpose of the present study was to determine whether chronic high-fatdiet (HF) induces insulin resistance independently of obesity. We randomlydivided 40 rats into two groups and fed them either with a HF or with a high-carbohydrate diet (HC) for 8 weeks. Whole body glucose disappearance rate (Rd) was measured using a euglycemic hyperinsulinemic clamp. Firstly, we defined whether insulin resistance by HF was associated with obesity. Plasma glucose and triglyceride concentrations were significantly increased in HF. Rd was decreased (10.6 +/- 0.2 vs. 9.1 +/- 0.2 mg/kg/min in HC and HF, respectively) and the hepatic glucose output rate (HGO) was increased in HF (2.2 +/- 0.3 vs. 4.5 +/- 0.2 mg/kg/min in HC and HF, respectively). Rd was significantly correlated with %VF (p < 0.01). These results implicate that visceral obesity is associated with insulin resistance induced by HF. In addition, to define whether dietary fat induces insulin resistance regardlessof visceral obesity, we compared Rd and HGO between groups 1) after matching %VF in both groups and 2) using an ANCOVA to adjust for %VF. After matching %VF, Rd in HF was significantly decreased by 14% (p < 0.001) and HGO was significantly increased by 110% (p < 0.001). Furthermore, statistical analyses using an ANCOVA also showed Rd for HF was Significantly decreased even after adjusting %VF. In conclusion, we suggest that dietary fat per se could induce insulin resistance in rats fed with chronic HF independently of obesity.

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Documento generato il 06/04/20 alle ore 01:58:24