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Titolo:
Evaluation of endovascular techniques for creating a porcine femoral artery occlusion model
Autore:
Nikol, S; Armeanu, S; Engelmann, MG; Pelisek, J; Fuchs, A; Zahringer, C; Bartoli, JM; Mesana, T; Rolland, PH;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Dept Med 1, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 , Dept Med 1, D-81377 Munich, Germany Univ Marseille, Lab Cardiovasc, Fac Med, Marseille, France Univ MarseilleMarseille France Cardiovasc, Fac Med, Marseille, France
Titolo Testata:
JOURNAL OF ENDOVASCULAR THERAPY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 401 - 407
SICI:
1526-6028(200108)8:4<401:EOETFC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEEDLE INJECTION CATHETER; VASCULAR OCCLUSION; GROWTH-FACTOR; BLOOD-FLOW; ANGIOGENESIS; GENE; STIMULATION; CIRCULATION; DISEASE; HEARTS;
Keywords:
ischemia; collateralization; blinded stent-graft; coils; detachable balloons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Nikol, S Univ Munich, Klinikum Grosshadern, Dept Med 1, Marchioninistr 15,D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 ch, Germany
Citazione:
S. Nikol et al., "Evaluation of endovascular techniques for creating a porcine femoral artery occlusion model", J ENDOVAS T, 8(4), 2001, pp. 401-407

Abstract

Purpose: To determine the optimal endovascular approach to achieve long-term occlusion of large arteries, while preserving the integrity of periarterial tissue, in an animal model of ischemia. Methods: Femoral artery occlusions were created in 16 pigs using detachable balloons, coils, or blinded stent-grafts. Feasibility, safety, primary and long-term success, and the degree of neovascularization were determined over a 6-month period by serial angiography and histological analyses. Four animals served as untreated controls. Results: Overall primary success for all occlusion devices was 100%. The 6-month occlusion rate using detachable balloons or coils was 33% and 0%, respectively; however, all arteries occluded with blinded stent-grafts remained obstructed to the end of the study. There was no significant difference in capillary densities and collateralization of periarterial areas when occluded arteries were compared with nonoccluded controls in the same animal. No increase in collateralization was observed following endovascular arterial occlusion. Conclusions: Percutaneous insertion of blinded stent-grafts easily, safely, and reliably creates long-term arterial occlusion in pigs, which may makethis a more appropriate model for studying the effects of angiogenic factors in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:51:21