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Titolo:
D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain
Autore:
Hurd, YL; Suzuki, M; Sedvall, GC;
Indirizzi:
Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychol Sect, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 ct, SE-17176 Stockholm, Sweden
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 1-2, volume: 22, anno: 2001,
pagine: 127 - 137
SICI:
0891-0618(200107)22:1-2<127:DADDRM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; PREFRONTAL CORTEX; I-125 EPIDEPRIDE; D-2-DOPAMINE RECEPTORS; WORKING-MEMORY; BASAL GANGLIA; SCHIZOPHRENIA; STRIATUM; NEURONS; LOCALIZATION;
Keywords:
dopamine receptors; in situ hybridization; neocortex; striatum; Islands of Calleja;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hurd, YL Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Psychol Sect, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 176 Stockholm, Sweden
Citazione:
Y.L. Hurd et al., "D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain", J CHEM NEUR, 22(1-2), 2001, pp. 127-137

Abstract

Understanding dopamine signaling in human behavior requires knowledge of the distribution of all molecular components involved in dopamine pathways throughout the human brain. In the present study, the relative distributionsof D1 and D2 dopamine receptor mRNAs were determined by in situ hybridization histochemistry in whole hemisphere sections from normal human post mortem brains. The findings confirmed information documented from single structure examination that the highest expression of both the D1 and D2 mRNAs were localized to the striatum. The cerebral cortex expressed moderate D1 mRNAin all regions with the highest signal in the medial orbital frontal area (Brodmann areas 11, 14), the paraterminal gyrus (Brodmann area 32) and the insular cortex (Brodmann areas 13-16), whereas the D2 mRNA expression had very low cortical expression. The bed nucleus of the stria terminalis and islands of Calleja had high expression of the D1 mRNA and moderate D2 mRNA levels. Moderate to high expression of the D2 mRNA was evident in the hippocampal formation, parafascicular and paraventricular thalamic nuclei, geniculate bodies, subthalamic nucleus, and pineal gland, all of which were devoidof, or showed only faint, D1 mRNA expression. Brainstem regions, e.g. substantia nigra, red nucleus, inferior colliculus, medial lemniscus, and pontine nuclei expressed D2, but not D1, mRNA. These results emphasize the differential anatomical localization or D1 and D2 dopamine receptor mRNA neuronal populations in the human brain. The restricted expression of the D1 mRNA to the cortical mantle and to a few forebrain structures indicates a stronginvolvement of the DI system in cognitive function. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 12:27:17