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Titolo:
Aminergic receptors during the development of the human brain: the contribution of in vitro imaging techniques
Autore:
del Olmo, E; Pazos, A;
Indirizzi:
Univ Cantabria, Dept Physiol & Pharmacol, Santander 39011, Spain Univ Cantabria Santander Spain 39011 & Pharmacol, Santander 39011, Spain
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 1-2, volume: 22, anno: 2001,
pagine: 101 - 114
SICI:
0891-0618(200107)22:1-2<101:ARDTDO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROSCOPIC AUTORADIOGRAPHIC LOCALIZATION; CHOLINERGIC BINDING-SITES; DENTATE GRANULE CELLS; 5-HT1A RECEPTORS; POSTNATAL-DEVELOPMENT; TRANSIENT EXPRESSION; MESSENGER-RNA; FUNCTIONAL-DEVELOPMENT; RAT FOREBRAIN; SEROTONIN;
Keywords:
autoradiography; development; human brain; in situ hybridization; prenatal; receptors; trophic effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Pazos, A Univ Cantabria, Dept Physiol & Pharmacol, Avda Herrera Oria S-N, Santander39011, Spain Univ Cantabria Avda Herrera Oria S-N Santander Spain39011 Spain
Citazione:
E. del Olmo e A. Pazos, "Aminergic receptors during the development of the human brain: the contribution of in vitro imaging techniques", J CHEM NEUR, 22(1-2), 2001, pp. 101-114

Abstract

The development of the human brain is a complex process and. in this regard, the maturation of neurotransmitter systems and their receptors is of special interest. The study of these systems requires methodological approaches with powerful anatomical resolution. In this paper we review the application of visualization procedures to the fine localization, pattern of appearance and functional relevance of monoaminergic receptors in postmortem human brain samples corresponding to different stages of development (fetal, neonatal, infant). Data obtained by using mostly in vitro autoradiography butalso in situ hybridization and, very recently, second messenger labeling. are discussed, including the methodological limitations inherent in workingwith inmature human tissue. From these studies, several conclusions were made. (1) It is possible to visualize, in the human brain with high resolution, the presence of neuroreceptors at early prenatal stages. (2) The anatomical distribution of monoaminergic receptors in the developing human brain is, in general terms, comparable to that found in the adult. (3) During thedevelopmental process, some receptors, which are early and sometimes transiently expressed, play important thophic roles in the regulation of neuronal development: this is the case with the serotonin 5-HT1A receptors, which attain peak levels of hyperexpression over the hippocampus (dentate gyrus, dendritic areas of CA fields) and the raphe nuclei and show a transient expression in the cerebellum, around the 25 week of gestational age. (4) Different patterns of ontogenetic appearance for human receptors have been identified: dopamine D-like (caudate, putamen, nigra) and 5-HT1A receptors are good examples of prenatal development, while 5-HT1B sites (basal ganglia, neocortex) present a mainly postnatal pattern of appearance. (5) Neurotransmitter receptors at human fetal stages are already functional from the point of view of transducing response. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:18:47