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Titolo:
Oxidative metabolism and the detection of neuronal activation via imaging
Autore:
Hoge, RD; Pike, GB;
Indirizzi:
McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Ctr, Montreal, PQ H3A 2B4, Canada Massachusetts Gen Hosp, Nucl Magnet Resonance Ctr, Charlestown, MA USA Massachusetts Gen Hosp Charlestown MA USA nance Ctr, Charlestown, MA USA
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 1-2, volume: 22, anno: 2001,
pagine: 43 - 52
SICI:
0891-0618(200107)22:1-2<43:OMATDO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; HUMAN VISUAL-CORTEX; OXYGEN-CONSUMPTION; STRIATE CORTEX; CORTICAL MICROCIRCULATION; FOREPAW STIMULATION; INTRINSIC SIGNALS; NEURAL ACTIVITY; FUNCTIONAL MRI;
Keywords:
oxidative metabolism; imaging; brain structures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Pike, GB McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, 3801 Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St MontrealPQ Canada H3A 2B4 A 2B4, Canada
Citazione:
R.D. Hoge e G.B. Pike, "Oxidative metabolism and the detection of neuronal activation via imaging", J CHEM NEUR, 22(1-2), 2001, pp. 43-52

Abstract

Recent years have witnessed a great growth of interest in non-invasive imaging methods, such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), permitting identification of brain structures that mediate specific cognitive and behavioural tasks in humans. Becausethese techniques use physiological responses such as increased perfusion or metabolism as surrogate indicators of evoked neuronal electrical activity, understanding the role of these processes in sustaining the information processing function of neurons is vital to the proper interpretation Of functional neuroimaging data. An ultimate goal of these non-invasive techniquesis to approach the sensitivity and spatial resolution of earlier autoradiographic methods, which have repeatedly demonstrated exquisitely detailed delineations of neuronal response patterns using metabolic glucose uptake as a physiological tag. Although glucose is generally metabolized ill conjunction with oxygen, technical challenges in imaging tissue oxygen Consumption in vivo have limited the use of this complementary process in the detectionof neuronal activation. In this article we review concepts linking cerebral blood flow and metabolism to neuronal activation, and compare functional imaging techniques that exploit these relationships. We also describe recently introduced MRI based methods for measurement of oxygen consumption and assess the relative contributions of different metabolic pathways during neuronal activation. Our calculations suggest that the bulk of the energy demand evoked during stimulation of neurons in visual cortex is met through Oxidative metabolism of glucose, supporting the use of oxygen uptake as a marker for increased neuronal electrical activity. (C) 2001 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:27:38