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Titolo:
Lack of evidence for association between endothelial nitric oxide synthasegene polymorphisms and coronary artery disease in the Australian Caucasianpopulation
Autore:
Granath, B; Taylor, RR; van Bockxmeer, FM; Mamotte, CDS;
Indirizzi:
Royal Perth Hosp, Dept Clin Immunol & Biochem Genet, Perth, WA 6847, Australia Royal Perth Hosp Perth WA Australia 6847 Genet, Perth, WA 6847, Australia Royal Perth Hosp, Dept Biochem, Perth, WA 6847, Australia Royal Perth Hosp Perth WA Australia 6847 ochem, Perth, WA 6847, Australia Univ Western Australia, Dept Pathol, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia Univ Western Australia, Dept Med, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia WA Heart Res Inst, Perth, WA, Australia WA Heart Res Inst Perth WA Australia eart Res Inst, Perth, WA, Australia
Titolo Testata:
JOURNAL OF CARDIOVASCULAR RISK
fascicolo: 4, volume: 8, anno: 2001,
pagine: 235 - 241
SICI:
1350-6277(200108)8:4<235:LOEFAB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL-INFARCTION; MOLECULAR MECHANISMS; HEART-DISEASE; NO SYNTHASE; VARIANT; RISK; MUTATION; INTRON-4;
Keywords:
coronary artery disease; endothelial nitric oxide; synthase polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Mamotte, CDS Royal Perth Hosp, Dept Clin Immunol & Biochem Genet, GPO Box X2213, Perth,WA 6847, Australia Royal Perth Hosp GPO Box X2213 Perth WA Australia 6847 tralia
Citazione:
B. Granath et al., "Lack of evidence for association between endothelial nitric oxide synthasegene polymorphisms and coronary artery disease in the Australian Caucasianpopulation", J CARD RISK, 8(4), 2001, pp. 235-241

Abstract

Background Genetic polymorphism in the gene for endothelial nitric oxide synthase (eNOS) has been identified as a potential risk factor for the development of premature coronary artery disease (CAD). We determined whether the eNOS 4ab, G894T, and T-786C polymorphisms are associated with premature coronary artery disease. Design A case-control study. Methods PCR-based assays were used to compare the frequency of eNOS gene polymorphisms in 573 Caucasian subjects aged under 50 years presenting with symptomatic CAD and documented by coronary angiography, with or without myocardial infarction, to that of 624 similarly aged community controls without a history of symptomatic CAD. Results We found no difference in the frequency of 4ab genotypes between cases and controls: in the CAD subjects, the 4aa, 4ab, and 4bb genotype frequencies were 1.9%, 24.3% and 73.8% respectively, compared to 2.2%, 25.5% and 72.3% respectively for the controls. There was also no significant difference between cases and controls in the frequency of any allele (4a/4b, 894G/894T, -786C/-786T), or genotype for any of the polymorphisms. Similarly, logistic regression analysis showed no evidence for an association of the polymorphisms with premature CAD or myocardial infarction or any indication of an interaction between the polymorphisms and other CAD risk factors, including smoking. Conclusions In a large case-control study, and in contrast to some earlierpositive findings by others, we have found no evidence for an association between several eNOS gene polymorphisms and premature CAD in an Australian Caucasian population. J Cardiovasc Risk 8:235-241 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:06:37