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Titolo:
Impaired fasting glucose, diabetes mellitus, and cardiovascular disease risk factors are associated with prolonged QTc duration. Results from the Third National Health and Nutrition Examination Survey
Autore:
Brown, DW; Giles, WH; Greenlund, KJ; Valdez, R; Croft, JB;
Indirizzi:
Div Adult & Community Hlth, Cardiovasc Hlth Branch, Atlanta, GA 30341 USA Div Adult & Community Hlth Atlanta GA USA 30341 ch, Atlanta, GA 30341 USA CDCP, Epidemiol & Stat Branch, Div Diabet Translat, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA CDCP Atlanta GA USA Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR RISK
fascicolo: 4, volume: 8, anno: 2001,
pagine: 227 - 233
SICI:
1350-6277(200108)8:4<227:IFGDMA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; AUTONOMIC CONTROL; BLOOD-PRESSURE; INTERVAL; INSULIN; POPULATION; GENDER; TONE; MORTALITY; ZUTPHEN;
Keywords:
cardiovascular disease; diabetes; epidemiology; QT duration; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Giles, WH Div Adult & Community Hlth, Cardiovasc Hlth Branch, 4770 Buford Hwy,MS K45, Atlanta, GA 30341 USA Div Adult & Community Hlth 4770 Buford Hwy,MS K45 Atlanta GA USA 30341
Citazione:
D.W. Brown et al., "Impaired fasting glucose, diabetes mellitus, and cardiovascular disease risk factors are associated with prolonged QTc duration. Results from the Third National Health and Nutrition Examination Survey", J CARD RISK, 8(4), 2001, pp. 227-233

Abstract

Background Impaired glucose tolerance and diabetes mellitus have been associated with a prolonged QT interval among select populations. However, these associations remain unclear among the general population. Methods We examined these relationships using data from 5833 adults aged 40-90 years from NHANES III (1988-1994). Univariate differences in cardiovascular disease (CVD) risk factors were examined across tertiles of heart rate corrected QT (QTc). The association between glucose intolerance, CVD riskfactors and a prolonged QTc (greater than or equal to0.440 s) was also assessed with logistic regression adjusting for age, race, gender, education, and heart rate. Results Prolonged QTc was observed among 22.0% of persons with normal glucose tolerance (NGT), 29.9% of those with impaired fasting glucose (IFG), and among 42.2% of persons with diabetes. Hypertension, serum cholesterol, obesity, heart rate, and fasting C-peptide and serum insulin levels were associated with prolonged QTc (all: P less than or equal to0.05). After multivariate adjustment, persons with IFG were 1.2 times (95% CI=0.7-2.0) as likely and persons with diabetes 1.6 times (95% CI=1.1-2.3) as likely to have a prolonged QTc as persons with NGT. In addition, persons with diabetes and two or more additional CVD risk factors were 2.3 times (95% CI=1.3-4.0) as likely to have a prolonged QTc as persons with NGT and no CVD risk factors after multivariate adjustment. Conclusion Diabetes was associated with an increased likelihood of prolonged QTc independent of age, race, gender, education, and heart rate. In addition, persons with diabetes and multiple CVD risk factors were more likely to have a prolonged QTc than those with NGT and no additional risk factors,suggesting that these persons may be at increased risk for cardiac arrhythmia and sudden death. J Cardiovasc Risk 2001,8:227-233 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 01:07:48