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Titolo:
Steroid hormone receptor-mediated histone deacetylation and transcription at the mouse mammary tumor virus promoter
Autore:
Sheldon, LA; Becker, M; Smith, CL;
Indirizzi:
Dartmouth Coll Sch Med, Dept Physiol, Lebanon, NH 03756 USA Dartmouth CollSch Med Lebanon NH USA 03756 hysiol, Lebanon, NH 03756 USA NCI, Lab Receptor Biol & Gene Express, Canc Res Ctr, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 ress, Canc Res Ctr, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 35, volume: 276, anno: 2001,
pagine: 32423 - 32426
SICI:
0021-9258(20010831)276:35<32423:SHRHDA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOCORTICOID RECEPTOR; SODIUM-BUTYRATE; CYCLIC-AMP; ACETYLATION; CHROMATIN; NUCLEOSOME; INDUCTION; BINDING; GENES; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sheldon, LA Dartmouth Coll Sch Med, Dept Physiol, 750W Borwell,1 Med Ctr Dr, Lebanon, NH 03756 USA Dartmouth Coll Sch Med 750W Borwell,1 Med Ctr Dr Lebanon NH USA 03756
Citazione:
L.A. Sheldon et al., "Steroid hormone receptor-mediated histone deacetylation and transcription at the mouse mammary tumor virus promoter", J BIOL CHEM, 276(35), 2001, pp. 32423-32426

Abstract

Acetylation of lysines in histones H3 and H4 N-terminal tails is associated with transcriptional activation and deacetylation with repression. Our studies with the mouse mammary tumor virus (MMTV) promoter in chromatin show significant levels of acetylation at promoter proximal and distal regions prior to transactivation. Upon activation with glucocorticoids or progestins, promoter proximal histones become deacetylated within the region of inducible nuclease hypersensitivity. The deacetylation lags behind the initiation of transcription, indicating a role in post-activation regulation. Our results indicate a novel mechanism by which target promoters are regulated bysteroid receptors and chromatin modification machinery.

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Documento generato il 05/04/20 alle ore 09:25:59