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Titolo:
Frequent increase of DNA copy number in the 2q24 chromosomal region and its association with a poor clinical outcome in hepatoblastoma: Cytogenetic and comparative genomic hybridization analysis
Autore:
Kumon, K; Kobayashi, H; Namiki, T; Tsunematsu, Y; Miyauchi, J; Kikuta, A; Horikoshi, Y; Komada, Y; Hatae, Y; Eguchi, H; Kaneko, Y;
Indirizzi:
Saitama Canc Ctr Hosp, Dept Canc Chemotherapy, Ina, Saitama 3620806, JapanSaitama Canc Ctr Hosp Ina Saitama Japan 3620806 a, Saitama 3620806, Japan Saitama Canc Ctr Hosp, Dept Med, Ina, Saitama 3620806, Japan Saitama Canc Ctr Hosp Ina Saitama Japan 3620806 a, Saitama 3620806, Japan Natl Childrens Hosp, Setagaya Ku, Tokyo 1548509, Japan Natl Childrens Hosp Tokyo Japan 1548509 etagaya Ku, Tokyo 1548509, Japan Fukushima Med Coll, Fukushima 9601247, Japan Fukushima Med Coll Fukushima Japan 9601247 oll, Fukushima 9601247, Japan Shizuoka Childrens Hosp, Shizuoka 4200953, Japan Shizuoka Childrens Hosp Shizuoka Japan 4200953 , Shizuoka 4200953, Japan Mie Univ, Tsu, Mie 5140001, Japan Mie Univ Tsu Mie Japan 5140001Mie Univ, Tsu, Mie 5140001, Japan Natl Sapporo Hosp, Shiroishi Ku, Sapporo, Hokkaido 0030804, Japan Natl Sapporo Hosp Sapporo Hokkaido Japan 0030804 Hokkaido 0030804, Japan Kurume Univ, Fukuoka 8300011, Japan Kurume Univ Fukuoka Japan 8300011Kurume Univ, Fukuoka 8300011, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 8, volume: 92, anno: 2001,
pagine: 854 - 862
SICI:
0910-5050(200108)92:8<854:FIODCN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN; GENETIC LINK; APC GENE; CANCER; RHABDOMYOSARCOMA; ABNORMALITIES; TRANSLOCATION; CHILDREN; TUMORS; WILMS;
Keywords:
hepatoblastoma; CGH; FISH; chromosome abnormalities; 2q gain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kaneko, Y Saitama Canc Ctr Hosp, Dept Canc Chemotherapy, 811 Komuro, Ina, Saitama 3620806, Japan Saitama Canc Ctr Hosp 811 Komuro Ina Saitama Japan 3620806 Japan
Citazione:
K. Kumon et al., "Frequent increase of DNA copy number in the 2q24 chromosomal region and its association with a poor clinical outcome in hepatoblastoma: Cytogenetic and comparative genomic hybridization analysis", JPN J CANC, 92(8), 2001, pp. 854-862

Abstract

In a cytogenetic and comparative genomic hybridization (CGH) study of 38 hepatoblastomas, we found gain of 1q in 17 tumors (44.7%), that of 2/2q in 14 (36.8%), that of 20/20q in 9 (23.7%) and that of 8/8q in 8 (21.0%), loss of 4q in 4 (10.5%) and no DNA copy changes with normal karyotype or no mitotic cells in 11 (28.9%). Eleven tumors with 2/2q gain detected by CGH had atotal chromosome 2 gain, a partial 2q gain, or a total chromosome 2 gain with an augmented partial 2q region; the common region for DNA copy gain was2q24. Two-color fluorescence in situ hybridization (FISH) analyses using probes covering the centromere of chromosome 2 or HOXD13 (2q31) confirmed the CGH findings, and showed that the common region for gain in 2q was centromeric to HOXD13. Event-free survival (EFS)+/- standard error (SE) at 5 years was lowest in patients with 2q gain [37 +/- 15%], highest in those with no DNA copy changes [82 +/- 12%], and intermediate in those with DNA copy changes other than 2q gain [74 +/- 13%] (P=0.0549). Multivariate analysis showed that 2q gain was an independent factor predicting a poor outcome. Thesefindings suggest the presence of a growth-promoting gene or an oncogene inthe 2q24 chromosome band, and a tumor suppressor gene in terminal 4q, which have important roles in the development and progression of hepatoblastoma.

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Documento generato il 01/04/20 alle ore 11:37:03