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Titolo:
Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats
Autore:
Minami, T; Kaneda, S; Otsuka, T; Jiao, ZX; Suzuki, Y; Yamada, T; Matsumoto, K; Izumi, K;
Indirizzi:
Univ Tokushima, Sch Med, Dept Pathol 2, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 athol 2, Tokushima 7708503, Japan Univ Tokushima, Sch Med, Dept Hyg, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 ept Hyg, Tokushima 7708503, Japan Univ Tokushima, Sch Med, Inst Anim Experimentat, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 imentat, Tokushima 7708503, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 8, volume: 92, anno: 2001,
pagine: 841 - 847
SICI:
0910-5050(200108)92:8<841:ROAGIS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVANS CINNAMON RATS; HEREDITARY HEPATITIS; LEC RATS; COPPER ACCUMULATION; WILSONS-DISEASE; D-PENICILLAMINE; LIVER; HEPATOCARCINOGENESIS; DIHYDROCHLORIDE; SUSCEPTIBILITY;
Keywords:
LEC rat; Atp7b; congenic; N-diethylnitrosamine; copper;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Izumi, K Univ Tokushima, Sch Med, Dept Pathol 2, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japan 7708503 apan
Citazione:
T. Minami et al., "Role of Atp7b gene in spontaneous and N-diethylnitrosamine-induced carcinogenesis in a new congenic strain, WKAH.C-Atp7b rats", JPN J CANC, 92(8), 2001, pp. 841-847

Abstract

To examine whether Long-Evans Cinnamon (LEC) rats, a mutant rat model of Wilson's disease, have a susceptibility gene(s) to hepatocarcinogenesis in addition to the causative gene, Atp7b, we established a new congenic strain,WKAH.C-Atp7b rats, in which the Atp7b gene of the LEC rats is inserted into the normal Wistar-King Aptekman Hokkaido (WKAH) background. Hepatocellular tumors developed spontaneously in both sexes of WKAH.C-Atp7b rats, their incidence being slightly lower than that in LEC rats. Incidences of spontaneous liver tumors in LEC, WKAH.C-Atp7b and WKAH rats correlated with hepatic copper and iron concentrations. Medium-term liver bioassay showed that LEC rats were more susceptible to the induction of glutathione S-transferase placental form-positive preneoplastic foci than WKAH.C-Atp7b rats, and WKAH. C-Atp7b rats were more susceptible than WKAH rats. In an N-diethylnitrosamine (DEN)-induced long-term carcinogenicity study, 1) LEC rats were similarly or rather less susceptible to hepatocellular tumors than WKAH.C-Atp7b and WKAH rats, indicating that the progression of the preneoplastic foci to liver cancer in LEC rats was worse than that in WKAH.C-Atp7b and WKAH rats, 2) the incidences of kidney tumors in LEC and WKAH.C-Atp7b rats were higherthan that in WKAH rats and high copper concentrations in the kidneys were observed in LEC and WKAH.C-Atp7b rats, 3) LEC rats were resistant to lung carcinogenesis. These data indicate that the susceptibility of LEC rats to liver and kidney carcinogenesis could be explained by Atp7b gene mutation and that the susceptibility to lung carcinogenesis is controlled by gene(s) other than Atp7b.

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Documento generato il 19/09/20 alle ore 21:20:54