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Titolo:
Glucose intolerance, plasma insulin levels, and colon adenomas in Japanesemen
Autore:
Nishii, T; Kono, S; Abe, H; Eguchi, H; Shimazaki, K; Hatano, B; Hamada, H;
Indirizzi:
Self Def Forces Fukuoka Hosp, Kasuga, Fukuoka 8160826, Japan Self Def Forces Fukuoka Hosp Kasuga Fukuoka Japan 8160826 8160826, Japan Kyushu Univ, Fac Med Sci, Dept Prevent Med, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ed, Higashi Ku, Fukuoka 8128582, Japan Kasukabe Kisen Hosp, Kasukabe, Saitama 3440067, Japan Kasukabe Kisen HospKasukabe Saitama Japan 3440067 Saitama 3440067, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 8, volume: 92, anno: 2001,
pagine: 836 - 840
SICI:
0910-5050(200108)92:8<836:GIPILA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLORECTAL-CANCER RISK; DIABETES-MELLITUS; PHYSICAL-ACTIVITY; SIGMOID COLON; CIGARETTE-SMOKING; CELL-LINE; OBESITY; RECEPTORS; ALCOHOL; GROWTH;
Keywords:
colon adenomas; glucose tolerance; plasma insulin; Japanese men; NIDDM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Nishii, T Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Tokorozawa Saitama Japan 3598513 98513, Japan
Citazione:
T. Nishii et al., "Glucose intolerance, plasma insulin levels, and colon adenomas in Japanesemen", JPN J CANC, 92(8), 2001, pp. 836-840

Abstract

Hyperinsulinemia may be related to colon carcinogenesis. Several studies have suggested that diabetes mellitus is related to increased risk of colon cancer. We examined cross-sectionally the relation of fasting plasma insulin levels and glucose tolerance status to colon adenomas. In a consecutive series of 951 men undergoing total colonoscopy for a health examination at the Japan Self Defense Forces Fukuoka Hospital from April 1998 to August 1999, we identified 233 cases of colon adenomas and 497 controls with normal colonoscopy. Glucose tolerance status was determined by a 75-g oral glucose tolerance test, and subjects were classified as normal, impaired glucose tolerance (IGT) or non-insulin dependent diabetes mellitus (NIDDM). Plasma insulin levels were measured after subjects had fasted overnight. Logistic regression analysis and analysis of covariance was used to control for age and obesity. While plasma insulin levels were unrelated to colon adenomas, NIDDM was associated with a significantly increased risk of colon adenomas. There was no association between IGT and colon adenomas. NIDDM was more strongly associated with proximal colon adenomas. The findings suggest that long-term hyperinsulinemic status associated with NIDDM may increase the risk of colon adenomas, and subsequently of colon cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:52:28