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Titolo:
Serological immunoglobulin G antibody titers to Helicobacter pylori in Japanese Brazilian and non-Japanese Brazilian gastric cancer patients and controls in Sao Paulo
Autore:
Fujioka, N; Fahey, MT; Hamada, GS; Nishimoto, N; Kowalski, LP; Iriya, K; Rodrigues, JJG; Tajiri, H; Tsugane, S;
Indirizzi:
Natl Canc Ctr, Res Inst E, Epidemiol & Biostat Div, Chiba 2778577, Japan Natl Canc Ctr Chiba Japan 2778577 ol & Biostat Div, Chiba 2778577, Japan Natl Def Med Coll, Dept Med Engn, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Tokorozawa Saitama Japan 3598513 Saitama 3598513, Japan Hosp Santa Cruz, Res Ctr, Nikkei Dis Prevent Ctr, BR-04122000 Sao Paulo, Brazil Hosp Santa Cruz Sao Paulo Brazil BR-04122000 BC4122000 Sao Paulo, Brazil AC Camargo Hosp, Res Ctr, BR-01509900 Sao Paulo, Brazil AC Camargo Hosp Sao Paulo Brazil BR-01509900 BC1509900 Sao Paulo, Brazil AC Camargo Hosp, Dept Head & Neck Surg, BR-01509900 Sao Paulo, Brazil AC Camargo Hosp Sao Paulo Brazil BR-01509900 BC1509900 Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Dept Gastroenterol, BR-01246904 Sao Paulo, BrazilUniv Sao Paulo Sao Paulo Brazil BR-01246904 BC01246904 Sao Paulo, Brazil Natl Shikoku Canc Ctr, Dept Clin Res, Matsuyama, Ehime 7900007, Japan NatlShikoku Canc Ctr Matsuyama Ehime Japan 7900007 Ehime 7900007, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 8, volume: 92, anno: 2001,
pagine: 829 - 835
SICI:
0910-5050(200108)92:8<829:SIGATT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLOW-UP; INTESTINAL-TYPE; MAJOR CANCERS; INFECTION; CARCINOMA; RISK; ASSOCIATION; ADENOCARCINOMAS; PREVALENCE; STOMACH;
Keywords:
Helicobacter pylori; antibody titer; gastric cancer; ethnicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Tsugane, S Natl Canc Ctr, Res Inst E, Epidemiol & Biostat Div, 6-5-1 Kashiwanoha, Chiba 2778577, Japan Natl Canc Ctr 6-5-1 Kashiwanoha Chiba Japan 2778577 577, Japan
Citazione:
N. Fujioka et al., "Serological immunoglobulin G antibody titers to Helicobacter pylori in Japanese Brazilian and non-Japanese Brazilian gastric cancer patients and controls in Sao Paulo", JPN J CANC, 92(8), 2001, pp. 829-835

Abstract

Helicobacter pylori (H. pylori) infection is considered a cause of gastriccancer (GC), though evidence for this association is scarce in high-risk areas. Possible case control and/or ethnic differences were investigated as to the presence of H. pylori and its immunogloblin G antibody titer in the multi-ethnic city of Sao Paulo, where the incidence of GC is relatively high. We performed a cross-sectional comparison of antibody titers to H. pylori in Japanese Brazilian, and non-Japanese Brazilian GC patients and their controls. Japanese Brazilian patients were matched by age, sex and ethnicitywith two controls, while non-Japanese Brazilian patients were matched as above with one control. Among Japanese Brazilians, 59 of 93 (63.4%) patientswith GC and 127 of 186 (68.3%) controls were positive for H. pylori-specific antibody (odds ratio (OR)=0.80, 95% confidence interval (Cl)=0.47-1.36),while among non-Japanese Brazilians, 171 of 228 patients with GC (75.7%) and 178 of 226 controls (78.8%) were positive (OR=0.84, 95% CI=0.54-1.30). The median serum antibody titer was lower in cases than in controls in both ethnic groups. A high titer (H. pylori titer greater than or equal to 50) was associated with less likelihood of GC for both ethnic groups (for Japanese Brazilians, OR=0.39, 95% CI=0.16-0.92; for non-Japanese Brazilians, OR=0.56, 95% CI=0.31-1.02). The high titer can be regarded as a sign of the necessity of eradication, and low titer is regarded as a sign of the necessityof close screening for GC in both ethnic groups, because extended atrophy may cause spontaneous disappearance of H. pylori from the stomach.

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Documento generato il 07/08/20 alle ore 07:03:00