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Titolo:
Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart
Autore:
Nakayama, H; Morozumi, T; Nanto, S; Shimonagata, T; Ohara, T; Takano, Y; Kotani, J; Watanabe, T; Fujita, M; Nishio, M; Kusuoka, H; Hori, M; Nagata, S;
Indirizzi:
Kansai Rosai Hosp, Div Cardiovasc, Amagasaki, Hyogo 6618511, Japan Kansai Rosai Hosp Amagasaki Hyogo Japan 6618511 aki, Hyogo 6618511, Japan Osaka Prefecture Hosp, Div Cardiovasc, Osaka, Japan Osaka Prefecture HospOsaka Japan re Hosp, Div Cardiovasc, Osaka, Japan Kagawa Univ, Sch Med, Dept Internal Med 2, Kagawa, Japan Kagawa Univ Kagawa Japan v, Sch Med, Dept Internal Med 2, Kagawa, Japan Osaka Natl Hosp, Inst Clin Res, Osaka, Japan Osaka Natl Hosp Osaka Japan saka Natl Hosp, Inst Clin Res, Osaka, Japan Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Suita, Osaka, Japan Osaka Univ Suita Osaka Japan ternal Med & Therapeut, Suita, Osaka, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 9, volume: 65, anno: 2001,
pagine: 783 - 787
SICI:
0047-1828(200109)65:9<783:AMFFAU>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; METABOLISM; FAILURE; CARDIOMYOPATHY; PRESSURE;
Keywords:
energy metabolism; free fatty acids; hypertensive heart; hypertrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Morozumi, T Kansai Rosai Hosp, Div Cardiovasc, 3-1-69 Inabaso, Amagasaki, Hyogo 6618511, Japan Kansai Rosai Hosp 3-1-69 Inabaso Amagasaki Hyogo Japan6618511
Citazione:
H. Nakayama et al., "Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart", JPN CIRC J, 65(9), 2001, pp. 783-787

Abstract

The left ventricle's morphological adaptation to high blood pressure is classified into 4 patterns based on mass and wall thickness. The geometric changes caused by maladaptation to pressure overload possibly relate to progression of contractile dysfunction with abnormal energy metabolism. The present study assessed whether the geometric adaptation of the left ventricle (LV) to high blood pressure relates to changes in myocardial energy metabolism, especially free fatty acid (FFA) utilization. Thirty-five patients withessential hypertension underwent echocardiography and dual isotopes myocardial scintigraphy using iodine-123 labeled 15-p-iodophenyl-3-(R,S)-methylpentadecanoic acid (BMIPP, an analogue of a FFA) and thallium-201 (Tl-201). Systolic (endocardial fractional shortening; %FS) and diastolic indices (theratio of early to atrial filling waves; E/A) of LV function were also assessed. Quantitative myocardial BMIPP uptake was evaluated by the BMIPP/Tl-201 myocardial uptake ratio (B/T). The subjects were divided into 4 groups based on LV mass and wall thickness: (1) concentric hypertrophy (CH), (2) eccentric hypertrophy (EH), (3) concentric remodeling (CR), and (4) normal geometry (N). The %FS was lower in the EH group than in the other groups. The mitral E/A ratio in the CH group was lowest. B/T was significantly decreased in the EH group compared with the N group (p <0.05). B/T correlated with the mitral E/A ratio significantly (p <0.05, r=0.42), whereas there was no relationship between %FS and B/T. These results indicate that the geometricchanges occurring in hypertensive hearts strongly correlate with alternations in cardiac function and with abnormal myocardial FFA metabolism, and that the latter is associated with diastolic abnormality, but not with systolic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 16:22:08