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Titolo:
Intermittent versus continuous sertraline therapy in the treatment of premenstrual dysphoric disorders
Autore:
Alpay, FB; Turhan, NO;
Indirizzi:
Fatih Univ, Sch Med, Dept Psychiat, Ankara, Turkey Fatih Univ Ankara Turkey h Univ, Sch Med, Dept Psychiat, Ankara, Turkey Fatih Univ, Sch Med, Dept Gynecol & Obstet, Ankara, Turkey Fatih Univ Ankara Turkey Sch Med, Dept Gynecol & Obstet, Ankara, Turkey
Titolo Testata:
INTERNATIONAL JOURNAL OF FERTILITY AND WOMENS MEDICINE
fascicolo: 4, volume: 46, anno: 2001,
pagine: 228 - 231
SICI:
1534-892X(200107/08)46:4<228:IVCSTI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; ANXIETY DISORDERS; LUTEAL-PHASE; DOUBLE-BLIND; PLACEBO; DEPRESSION; CROSSOVER; WOMEN;
Keywords:
premenstrual dysphoric disorder; sertraline; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Alpay, FB Bilkent Univ, Merkez Kampus Lojmanlari,39-5, TR-06533 Ankara, Turkey Bilkent Univ Merkez Kampus Lojmanlari,39-5 Ankara Turkey TR-06533
Citazione:
F.B. Alpay e N.O. Turhan, "Intermittent versus continuous sertraline therapy in the treatment of premenstrual dysphoric disorders", INT J F W M, 46(4), 2001, pp. 228-231

Abstract

Objective-Premenstrual dysphoric disorder (PMDD) is a combination of mood disturbances and physical symptoms that reduce the quality of individual life and the functionality of the individual. Many women do not consider the complaints arising in the luteal phase of the menstrual cycle as a psychiatric disorder and, thus, do not seek treatment. Those who take their complaints to doctors usually apply to gynecology clinics. The aim of the present study is to analyze the psychiatric disorders observed in patients with PMDD and to compare the continuous and intermittent administration of sertraline. Materials and Methods-PA-IDD was investigated in the patients admitted to the Gynecology Clinic of the Medical School of Fatih University. The patients were asked to fill out forms designed in accordance with PMDD diagnosis criteria as defined in DSM IV. Results-Among the 267 patients who filledout the forms, 162 (60.7%) were PMDD positive. Of the PMDD-positive patients, 133 accepted a psychiatric interview; 36 (27%) of them had depression, obsessive-compulsive disorder, anxiety and somatoform disorders as an accompanying disorder. Out of 162 PMDD-positive patients 94 accepted medical treatment; 71 patients were given sertraline on a continuous basis, and 23 patients took sertraline intermittently in the luteal phase of the cycle. Because of side effects, 44 (62%) of the continuous therapy and 22 (96%) of theintermittent therapy group stopped medication. At the end of 6-month follow-up, continuous use of sertraline was found to be significantly more tolerated than intermittent therapy in the treatment of PMDD (chi (2) 7.88, p = 0.005). Conclusion-In patients with the symptoms of PMDD, psychiatric evaluation should be encouraged by gynecology clinics, and continuous administration of sertraline should be the choice because of patients' greater acceptance of the therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:56:25