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Titolo:
Malignant mesothelioma - German mesothelioma register 1987-1999
Autore:
Neumann, V; Gunther, S; Muller, KM; Fischer, M;
Indirizzi:
Univ Hosp, Bergmannsheil Bochum, Clin Workers Compensat Boards, Inst Cent Federat Ind Berufsgenossenschaften,Germ, D-44789 Bochum, Germany Univ HospBochum Germany D-44789 nschaften,Germ, D-44789 Bochum, Germany
Titolo Testata:
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
fascicolo: 6, volume: 74, anno: 2001,
pagine: 383 - 395
SICI:
0340-0131(200108)74:6<383:MM-GMR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASBESTOS-RELATED MESOTHELIOMA; MINERAL FIBER CONTENT; LONG-TERM SURVIVAL; PLEURAL MESOTHELIOMA; LUNG-TISSUE; PERITONEAL MESOTHELIOMA; CHRYSOTILE ASBESTOS; INSULATION WORKERS; FACTORY-WORKERS; ENGLISH REGION;
Keywords:
malignant mesothelioma; subtype; asbestos; occupation; survival time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Fischer, M Univ Hosp, Bergmannsheil Bochum, Clin Workers Compensat Boards,Inst Cent Federat Ind Berufsgenossenschaften,Germ, Burkle Camp Pl 1, D-44789 Bochum, Germany Univ Hosp Burkle Camp Pl 1 Bochum Germany D-44789 hum, Germany
Citazione:
V. Neumann et al., "Malignant mesothelioma - German mesothelioma register 1987-1999", INT A OCCUP, 74(6), 2001, pp. 383-395

Abstract

Objectives: The study group comprised a collective of 1,605 patients with malignant mesotheliomas and with lung tissue available for lung dust analyses. Method: Clinical features, occupational histories, expositions and individual data were evaluated, and the asbestos bodies concentrations (asbestos bodies/cm(3) lung tissue or g wet tissue) were determined. Results: Mesotheliomas developed mainly in men (94.5%). Of the cases, 96.4% were of pleural origin and only 3.3% were peritoneal mesotheliomas. The biphasic subtypepredominated (61.3%), followed by the epithelioid type (29.3%). The sarcomatoid subtype was rarely developed (9.4%). Mean age at first diagnosis was 60.4 years. The mean survival time from time of symptom onset was 13.5 months. Patients with epithelioid subtypes had a longer survival time (16.9 months) than those with biphasic (13.1 months) and sarcomatoid subtypes (5.5 months). Of the patients, 73% presented pleural effusions as initial symptoms of the disease. An increased asbestos burden was identified by light microscopy in 84.8% of the patients. There was no association between histological subtypes and the asbestos burden of the lungs. Patients with peritonealmesotheliomas had distinctly higher asbestos burdens in the lungs than patients with pleural mesotheliomas. There exists no association between lung asbestos burdens and survival times. The mean latency period was 37.8 years. A trend: higher asbestos burden of the lung/shorter latency periods was suggested. About 70% of the patients had a history of occupational exposure to asbestos dust. Most patients worked in the building trade, the locksmithand machine building industries and in the steel and blast-furnace industries. Of the patients, 25.6% had asbestos-associated lung fibroses, in 40.7%of the cases pleural plaques were identified. Conclusions: The most important causal factor for development of mesotheliomas is still asbestos, primarily amphibole asbestos. The recurring occurrence of mesotheliomas in younger people without known asbestos exposure needs the urgent investigation ofother inducing factors for mesotheliomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:56:08