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Titolo:
Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of notch-1
Autore:
Koch, U; Lacombe, TA; Holland, D; Bowman, JL; Cohen, BL; Egan, SE; Guidos, CJ;
Indirizzi:
Hosp Sick Children, Res Inst, Program Dev Biol, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Univ Toronto, Dept Immunol, Toronto, ON M5G 1X8, Canada Univ Toronto Toronto ON Canada M5G 1X8 munol, Toronto, ON M5G 1X8, Canada Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5G 1X8, Canada Univ Toronto Toronto ON Canada M5G 1X8 Genet, Toronto, ON M5G 1X8, Canada
Titolo Testata:
IMMUNITY
fascicolo: 2, volume: 15, anno: 2001,
pagine: 225 - 236
SICI:
1074-7613(200108)15:2<225:SOTTLD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL FATE; THYMOCYTE DEVELOPMENT; DROSOPHILA EYE; ALPHA-BETA; STEM-CELLS; B-CELL; EXPRESSION; GLYCOSYLTRANSFERASE; BOUNDARY; CHOICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Guidos, CJ Hosp Sick Children, Res Inst, Program Dev Biol, 555 Univ Ave, Toronto, ON M5G 1X8, Canada Hosp Sick Children 555 Univ Ave Toronto ON Canada M5G 1X8 anada
Citazione:
U. Koch et al., "Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of notch-1", IMMUNITY, 15(2), 2001, pp. 225-236

Abstract

Notch-1 signaling is essential for lymphoid progenitors to undergo T cell commitment, but the mechanism has not been defined. Here we show that thymocytes ectopically expressing Lunatic Fringe, a modifier of Notch-1 signaling, induce lymphoid progenitors to develop into B cells in the thymus. This cell fate switch resulted from Lunatic Fringe-mediated inhibition of Notch-1 function, as revealed by experiments utilizing lymphoid progenitors in which Notch-1 activity was genetically manipulated. These data identify Lunatic Fringe as a potent regulator of Notch-1 during the T/B lineage decision and show that an important function of Notch-1 in T cell commitment is to suppress B cell development in the thymus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:08:39