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Titolo:
Reduced p21(WAF1/CIP1) expression is an early event in gallbladder carcinogenesis and is of prognostic significance for patients with carcinomas of the gallbladder
Autore:
Li, X; Hui, AM; Shi, YZ; Takayama, T; Makuuchi, M;
Indirizzi:
Univ Tokyo, Hepato Biliary Pancreat Surg Div, Dept Surg, Grad Sch Med,Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 d Sch Med,Bunkyo Ku, Tokyo 1138655, Japan
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 8, volume: 32, anno: 2001,
pagine: 771 - 777
SICI:
0046-8177(200108)32:8<771:RPEIAE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN EXPRESSION; P53 PROTEIN; HEPATOCELLULAR CARCINOMAS; SURGICAL-TREATMENT; TUMOR SUPPRESSION; LESIONS; P21; INHIBITOR; PROGRESSION; MUTATIONS;
Keywords:
gallbladder carcinoma; precancerous lesion; prognosis; p21(WAF1/CIP1); p53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hui, AM Univ Tokyo, Hepato Biliary Pancreat Surg Div, Dept Surg, Grad Sch Med,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 , Tokyo 1138655, Japan
Citazione:
X. Li et al., "Reduced p21(WAF1/CIP1) expression is an early event in gallbladder carcinogenesis and is of prognostic significance for patients with carcinomas of the gallbladder", HUMAN PATH, 32(8), 2001, pp. 771-777

Abstract

The molecular basis underlying the development and progression of gallbladder carcinoma (GBC) remains poorly understood. To evaluate the roles of p21(WAF1/CIP1) and p53 in gallbladder carcinogenesis and to assess their prognostic significance for patients with GBC, we used immunohistochemistry to examine the expression of p21(WAF1/CIP1) and p53 protein in a series of surgically resected specimens, including normal epithelia, precancerous lesionsadenoma, and dysplasia, and carcinomas of the gallbladder. Reduced p21(WAF1/CIP1) expression was frequently observed in carcinomas (18 of 37 lesions;49%), and even in precancerous lesions adenomas (3 of 7; 43%) and dysplasias (5 of 5; 100%). p53 overexpression was detected in 43% of the adenomas, 60% of the dysplasias and 57% of the carcinomas. There was an inverse relationship between p21(WAF1/CIP1) and p53 expression in GBCs (P =.01). Survival analysis indicated that reduced p21(WAF1/CIP1) expression was significantly associated with shortened disease-free and overall survival (P=.04 and .03, respectively) for patients with stages II to IV GBCs. These observations suggest that reduced p21(WAF1/CIP1) expression and p53 overexpression contribute to GBC from an early stage and that determination of p21(WAF1/CIP1)expression in surgically resected specimens would add prognostic information to conventional pathologic examinations for patients with advanced-stageGBC. HUM PATHOL 32: 771-777. (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:49:43