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Titolo:
Vasomotor effects of L- and D-arginine in stenotic atheromatous coronary plaque
Autore:
Tousoulis, D; Davies, GJ; Tentolouris, C; Goumas, G; Stefanadis, C; Toutouzas, P;
Indirizzi:
Hammersmith Hosp, Imperial Coll Sch Med, London W12 0NN, England Hammersmith Hosp London England W12 0NN Sch Med, London W12 0NN, England Univ Athens, Sch Med, Hippokrat Hosp, Cardiol Unit, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 Cardiol Unit, GR-11527 Athens, Greece
Titolo Testata:
HEART
fascicolo: 3, volume: 86, anno: 2001,
pagine: 296 - 301
SICI:
1355-6037(200109)86:3<296:VEOLAD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATION; ACUTE MYOCARDIAL-INFARCTION; CHOLESTEROL-FED RABBITS; NITRIC-OXIDE SYNTHESIS; STABLE ANGINA; HYPERCHOLESTEROLEMIC RABBIT; MATRIX METALLOPROTEINASES; STENOSIS MORPHOLOGY; UNSTABLE ANGINA; ARTERY DISEASE;
Keywords:
endothelium; coronary artery disease; L-arginine; vasomotor tone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Davies, GJ Hammersmith Hosp, Imperial Coll Sch Med, Du Cane Rd, London W120NN, England Hammersmith Hosp Du Cane Rd London England W12 0NN NN, England
Citazione:
D. Tousoulis et al., "Vasomotor effects of L- and D-arginine in stenotic atheromatous coronary plaque", HEART, 86(3), 2001, pp. 296-301

Abstract

Objective-To examine the effects of exogenous L- and D-arginine on coronary stenosis vasomotion in relation to stenosis morphology. Design-Intracoronary infusions of normal saline, L- and D-arginine (50 and150 pmol/min), and glyceryl trinitrate (250 mug bolus) were given in 24 patients with coronary artery disease and stable angina. Coronary stenoses were classified as smooth or complex (irregular borders). The diameter of thecoronary stenoses and their adjacent reference segments was measured by computed quantitative angiography. Results-During L-arginine infusion a larger proportion of complex stenosesthan smooth stenoses dilated by greater than or equal to 10% (p < 0.01), and the magnitude of dilatation was greater at the site of complex stenoses (p < 0.05). Irrespective of the type of morphology there was a positive correlation (p < 0.01) between the severity of stenoses and the magnitude of vasodilatation to L-arginine. The response to glyceryl trinitrate was similar in the two groups. No significant change was found in either group in response to D-arginine. Conclusions-In patients with coronary artery disease, coronary stenoses-particularly those of complex morphology-dilate in response to the administration of L-arginine but not D-arginine. This finding is consistent with partial deficiency of the substrate for nitric oxide synthesis, L-arginine, at the site of complex stenoses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:23:23