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Titolo:
Geographic variation in incidence of coronary heart disease in Britain: the contribution of established risk factors
Autore:
Morris, RW; Whincup, PH; Lampe, FC; Walker, N; Wannamethee, SG; Shaper, AG;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Primary Care & Populat Sci, London NW3 2PF, England Royal Free & Univ Coll Med Sch London England NW3 2PF n NW3 2PF, England Univ London St Georges Hosp, Dept Publ Hlth Sci, London, England Univ London St Georges Hosp London England bl Hlth Sci, London, England
Titolo Testata:
HEART
fascicolo: 3, volume: 86, anno: 2001,
pagine: 277 - 283
SICI:
1355-6037(200109)86:3<277:GVIIOC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGED BRITISH MEN; BLOOD-PRESSURE; CARDIOVASCULAR MORTALITY; SOCIAL-CLASS; LIFE-STYLE; ENGLAND; WALES; DEPRIVATION; STROKE; ASSOCIATION;
Keywords:
geographic variation; established risk factors; coronary heart disease; multilevel modelling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Morris, RW Royal Free & Univ Coll Med Sch, Dept Primary Care & Populat Sci, Royal Free Campus,Rowland Hill St, London NW3 2PF, England Royal Free & Univ Coll Med Sch Royal Free Campus,Rowland Hill St London England NW3 2PF
Citazione:
R.W. Morris et al., "Geographic variation in incidence of coronary heart disease in Britain: the contribution of established risk factors", HEART, 86(3), 2001, pp. 277-283

Abstract

Objective-To determine the extent to which geographic variation in the incidence of major coronary heart disease (CHD) in Great Britain may be explained by established risk factors. Design-Prospective study. Setting-24 British towns with widely differing CHD mortality. Subjects-7735 men followed up from screening in 1978-80 for 15 years. Main outcome measures-Percentage of variance between the towns in major CHD incidence that can be explained by individual characteristics of men in the towns. Results Age standardised incidence rates over a 15 year period varied from0.52% per annum in Maidstone to 1.07% per annum in Dewsbury and tended to follow the known pattern of higher rates in Scottish and northern English towns and lower rates in southern English towns ("north-south gradient"). Higher town incidence rates were related to prevalence of current cigarette smoking, low physical activity, and low alcohol consumption, and to mean body mass index, mean systolic blood pressure, low mean height, and prevalenceof manual social class, but not to mean serum total cholesterol. The 95% range for true age adjusted CHD incidence (over 15 years) was estimated as 0.58-1.03% per annum among British towns. After adjustment for baseline smoking status, physical activity, body mass index, alcohol consumption, systolic blood pressure, serum total cholesterol, occupational social class, and height, this variation was reduced by 50%. A model based on these eight variables accounted for the major part of the north-south gradient. Conclusions-Much of the variation in CHD incidence among British towns wasaccounted for by established risk variables. The remaining unexplained variation may be related to measurement error in the established risk variables, to environmental factors such as climate, or to the combined effect of awide range of minor risk factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:58:16