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Titolo:
Carboplatin-induced oxidative stress in rat cochlea
Autore:
Husain, K; Whitworth, C; Somani, SM; Rybak, LP;
Indirizzi:
So Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 acol, Springfield, IL 62794 USA So Illinois Univ, Sch Med, Dept Surg, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 Surg, Springfield, IL 62794 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 159, anno: 2001,
pagine: 14 - 22
SICI:
0378-5955(200109)159:1-2<14:COSIRC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CISPLATIN-INDUCED OTOTOXICITY; OVARIAN-CANCER; NITRIC-OXIDE; ANTIOXIDANT SYSTEM; GUINEA-PIGS; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; SODIUM THIOSULFATE; LIPOIC ACID; PROTECTION;
Keywords:
carboplatin; oxidative stress; cochlear antioxidant; lipid peroxidation; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Husain, K So Illinois Univ, Sch Med, Dept Pharmacol, 801 N Rutledge, Springfield, IL62794 USA So Illinois Univ 801 N Rutledge Springfield IL USA 62794 794 USA
Citazione:
K. Husain et al., "Carboplatin-induced oxidative stress in rat cochlea", HEARING RES, 159(1-2), 2001, pp. 14-22

Abstract

Carboplatin is currently being used in the clinic against a variety of human cancers. However, high dose carboplatin chemotherapy resulted in ototoxicity in cancer patients. This is the first study to show carboplatin-induccd oxidative stress response in the cochlea of rat, Male Wistar rats were divided into two groups of six animals each and treated as follows: (1) control (normal saline, i.p.) and (2) carboplatin (256 mg/kg, i.p.). Animals in both groups; were sedated with ketamine/xylazine and auditory brainstem-evoked responses were recorded before and 4 days after treatments. The animalswere sacrificed on the fourth day and cochleae were harvested and analyzed. A significant elevation of the hearing threshold shifts was noted at clicks, 8, 16, and 32 kHz tone burst stimuli following carboplatin administration. Carboplatin significantly increased nitric oxide and malondialdehyde levels, xanthine oxidase and manganese-superoxide dismutase activities in thecochlea indicating enhanced flux of free radicals. Cochlear glutathione levels, antioxidant enzyme activities such as copper zinc-superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase and enzyme protein levels were significantly depleted 4 days after carboplatin treatment. The data suggest that carboplatin induced freeradical generation and antioxidant depletion, and caused oxidative injury in the cochleae of rats. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:33:20