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Titolo:
AV.TK-mediated killing of subcutaneous tumors in situ results in effectiveimmunization against established secondary intracranial tumor deposits
Autore:
Okada, T; Shah, M; Higginbotham, JN; Li, Q; Wildner, O; Walbridge, S; Oldfield, E; Blaese, RM; Ramsey, WJ;
Indirizzi:
NHGRI, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA NHGRI Bethesda MD USA 20892 e Therapy Branch, NIH, Bethesda, MD 20892 USA NINDS, Surg Neurol Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 rg Neurol Branch, NIH, Bethesda, MD 20892 USA Baylor Coll Med, Dept Internal Med, Houston, TX 77030 USA Baylor Coll MedHouston TX USA 77030 Internal Med, Houston, TX 77030 USA
Titolo Testata:
GENE THERAPY
fascicolo: 17, volume: 8, anno: 2001,
pagine: 1315 - 1322
SICI:
0969-7128(200109)8:17<1315:AKOSTI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERPES-SIMPLEX VIRUS; MALIGNANT BRAIN-TUMORS; VECTOR PRODUCER CELLS; KINASE GENE-THERAPY; MHC CLASS-I; ANTITUMOR IMMUNITY; HSV-TK; RETROVIRAL VECTORS; ADENOVIRAL VECTOR; GLIOMA-CELLS;
Keywords:
glioma; cancer vaccine; in situ; adenovirus; HSVtk;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Okada, T Jichi Med Sch, Ctr Mol Med, Div Genet Therapeut, 3311-1 YakushijiMinami Kawachi, Kawachi, Tochigi 3290498, Japan Jichi Med Sch 3311-1 Yakushiji Minami Kawachi Kawachi Tochigi Japan 3290498
Citazione:
T. Okada et al., "AV.TK-mediated killing of subcutaneous tumors in situ results in effectiveimmunization against established secondary intracranial tumor deposits", GENE THER, 8(17), 2001, pp. 1315-1322

Abstract

Gene transfer vectors expressing herpes simplex thymidine kinase (HSVtk), in addition to direct killing of tumor cells, often have an associated local 'bystander effect' mediated by metabolic coupling of tumor cells. A systemic antitumor effect mediated by the immune system, termed the distant bystander effect, has also been reported. We have observed the development of cytotoxic T-lymphocyte (CTL) populations and long-lasting antitumor immunityfollowing treatment of subcutaneous tumors with an adenoviral vector expressing HSVtk (AV.TK) and ganciclovir (GCV) in rat glioma model. This vaccination effect seen with AV.TK/GCV treatment of subcutaneous tumor could even abrogate or retard growth of previously established secondary intracranial tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:43:51