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Titolo:
Immunohistochemical quantification of pulmonary mast-cells and post-mortemblood dosages of tryptase and eosinophil cationic protein in 48 heroin-related deaths
Autore:
Fineschi, V; Cecchi, R; Centini, F; Reattelli, LP; Turillazzi, E;
Indirizzi:
Univ Foggia, Inst Med Legale, Osped Riuniti, I-71100 Foggia, Italy Univ Foggia Foggia Italy I-71100 e, Osped Riuniti, I-71100 Foggia, Italy Univ Roma La Sapienza, Inst Legal Med, I-00100 Rome, Italy Univ Roma La Sapienza Rome Italy I-00100 Legal Med, I-00100 Rome, Italy Univ Siena, Policlin Le Scotte, Unit Forens Toxicol, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 Unit Forens Toxicol, I-53100 Siena, Italy Univ Perugia, Inst Med Legale, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100 st Med Legale, I-06100 Perugia, Italy
Titolo Testata:
FORENSIC SCIENCE INTERNATIONAL
fascicolo: 3, volume: 120, anno: 2001,
pagine: 189 - 194
SICI:
0379-0738(20010901)120:3<189:IQOPMA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUDDEN-INFANT-DEATH; ANAPHYLAXIS; POSTMORTEM; DIAGNOSIS; MORPHINE; DRUGS; SERUM; ACTIVATION; HISTAMINE; ANTIBODY;
Keywords:
heroin overdose; mast-cell tryptase eosinophil cationic protein; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Fineschi, V Univ Foggia, Inst Med Legale, Osped Riuniti, Via L Pinto 1, I-71100 Foggia, Italy Univ Foggia Via L Pinto 1 Foggia Italy I-71100 Foggia, Italy
Citazione:
V. Fineschi et al., "Immunohistochemical quantification of pulmonary mast-cells and post-mortemblood dosages of tryptase and eosinophil cationic protein in 48 heroin-related deaths", FOREN SCI I, 120(3), 2001, pp. 189-194

Abstract

Recent studies suggest that many fatal heroin overdoses are caused by anaphylactoid reaction. In the present study we measured tryptase and eosinophil cationic protein in post-mortem blood of 48 deaths after heroin injection. We also investigated the presence and pulmonary distribution of mast-cells using specific immunohistochemical antibody for tryptase and morphometricevaluation in those cases of heroin-related deaths. The data were comparedwith 44 subjects who died following head trauma and to 32 cases of fatal anaphylactic shock. In the heroin-related death cases, the measurements of serum tryptase levels and eosinophil cationic protein dosages resulted in particularly elevated concentrations compared with the trauma cases. Nevertheless, the data that our study supplies by immunohistochemical techniques indicate that when mast-cells count in the lung was determined, no definite pattern was obtained between fatal heroin overdose cases and the control groups. Furthermore, the wide range of morphine concentrations found in post-mortem blood samples suggest that the term 'overdose' is relative and does not sufficiently characterize death associated with heroin addiction. Our study confirms that elevated concentrations of serum tryptase are associated with many heroin-related deaths. At this moment to attribute the cause of these deaths to 'heroin overdose' ignores the likely causal contribution of other possible systemic reactions to the mechanism of death. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:39:06