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Titolo:
Telomerase activity in Kaposi's sarcoma, squamous cell carcinoma, and basal cell carcinoma
Autore:
Chen, ZP; Smith, KJ; Skelton, HG; Barrett, TL; Greenway, HT; Lo, SC;
Indirizzi:
Armed Forces Inst Pathol, Dept Infect & Parasit Dis Pathol, Washington, DC20306 USA Armed Forces Inst Pathol Washington DC USA 20306 Washington, DC20306 USA Amer Registry Pathol, Washington, DC 20306 USA Amer Registry Pathol Washington DC USA 20306 ol, Washington, DC 20306 USA Amer Registry Pathol, Washington, DC 20306 USA Amer Registry Pathol Washington DC USA 20306 ol, Washington, DC 20306 USA Natl Naval Med Res Inst, Bethesda, MD 20889 USA Natl Naval Med Res Inst Bethesda MD USA 20889 nst, Bethesda, MD 20889 USA Lab Corp Amer, Herndon, VA 20171 USA Lab Corp Amer Herndon VA USA 20171Lab Corp Amer, Herndon, VA 20171 USA Scripps Clin, La Jolla, CA 92037 USA Scripps Clin La Jolla CA USA 92037Scripps Clin, La Jolla, CA 92037 USA Johns Hopkins Med Ctr, Baltimore, MD 21287 USA Johns Hopkins Med Ctr Baltimore MD USA 21287 Ctr, Baltimore, MD 21287 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 8, volume: 226, anno: 2001,
pagine: 753 - 757
SICI:
1535-3702(200109)226:8<753:TAIKSS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMOSEXUAL MEN; HUMAN SKIN; CANCER; REGRESSION; EXPRESSION; ACTIVATION; AIDS;
Keywords:
telomerase; Kaposi's sarcoma; malignancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Lo, SC Armed Forces Inst Pathol, Dept Infect & Parasit Dis Pathol, Bldg 54,Room 4091,14th & Alaska Ave,NW, Washington, DC 20306 USA Armed Forces InstPathol Bldg 54,Room 4091,14th & Alaska Ave,NW Washington DC USA 20306
Citazione:
Z.P. Chen et al., "Telomerase activity in Kaposi's sarcoma, squamous cell carcinoma, and basal cell carcinoma", EXP BIOL ME, 226(8), 2001, pp. 753-757

Abstract

Patients with acquired immune deficiency syndrome (AIDS) often develop Kaposi's sarcoma (KS), an unusual skin tumor. The malignant nature of KS has long been disputed. Telomerase activity that maintains telomere length and ensures chromosomal stability, a frequently appearing marker in human malignancies, has been proposed to play a critical role in supporting continued cell growth, hence formation of tumors. We examined telomerase activity in tissue extracts from 22 KS, 10 squamous cell carcinoma (SCC), and 22 basal cell carcinoma (BCC) using the telomeric repeat amplification protocol (TRAP). All of the tumor tissues were previously cryopreserved at -80 degreesC. In this study, all tumor samples tested were positive for telomerase activity. Consistent with the presence of the enzyme activity, the skin tumors had relatively long telomeres. Inhibitors in the tissue extracts of some samples needed to be diluted or extracted by phenol before the enzyme activity was detected in the TRAP assay. All KS as well as two other skin carcinoma samples revealed positive telomerase activity. Our finding supports telomerase's role in tumor cell immortality and suggests the true neoplastic nature of KS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:16:56