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Titolo:
Dehydroepiandrosterone alters Zucker rat soleus and cardiac muscle lipid profiles
Autore:
Abadie, JM; Malcom, GT; Porter, JR; Svec, F;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Pathol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Louisiana State Univ, Med Ctr, Dept Physiol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Louisiana State Univ, Med Ctr, Dept Med, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 8, volume: 226, anno: 2001,
pagine: 782 - 789
SICI:
1535-3702(200109)226:8<782:DAZRSA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID COMPOSITION; DEPENDENT DIABETES-MELLITUS; INSULIN-RESISTANCE; DIETARY-FAT; GLUCOSE-TOLERANCE; SKELETAL-MUSCLE; ADIPOSE-TISSUE; METABOLISM; NIDDM; SERUM;
Keywords:
fatty acids; insulin resistance; Zucker Rats; DHEA; PPAR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Abadie, JM Madigan Army Med Ctr, Ft Lewis, WA 98431 USA Madigan Army Med Ctr Ft Lewis WA USA 98431 Lewis, WA 98431 USA
Citazione:
J.M. Abadie et al., "Dehydroepiandrosterone alters Zucker rat soleus and cardiac muscle lipid profiles", EXP BIOL ME, 226(8), 2001, pp. 782-789

Abstract

High levels of serum free fatty acids (FFA) and lower proportions of polyunsaturated (PU) FAs, specifically arachidonic acid (AA), are common in obesity, insulin resistance (IR), and type 2 diabetes mellitus. Dehydrepiandrosterone (DHEA) decreases body fat content, dietary fat consumption, and insulin levels in obese Zucker rats (ZR), a genetic model of human youth onset obesity and type 2 diabetes. This study was conducted to investigate DHEA'seffects on lean and obese ZR serum FFA levels and total lipid (TL) FA profiles in heart and soleus muscle. We postulated that DHEA alters serum FFA levels and tissue TIL FA profiles of obese ZR so that they resemble the levels and profiles of lean ZR. If so, DHEA may directly or indirectly alter tissue lipids, FFA flux, and perhaps lower IR in obese ZR. Lean and obese male ZR were divided into six groups with 10 animals in each: obese ad libitumcontrol, obese pair-fed, obese DHEA, lean ad libitum control, lean pair-fed, and lean DHEA. All animals had ad libitum access to a diet whose calories were 50% fat, 30% carbohydrate, and 20% protein. Only the diets of the DHEA treatment groups were supplemented with 0.6% DHEA. Pair-fed groups were given the average number of calories per day consumed by their corresponding DHEA group, and ad libitum groups had 24-h access to the DHEA-free diet. Serum FFA levels and heart and soleus TL FA profiles were measured. Serum FFA levels were higher in obese (similar to1 mmol/L) compared to lean (similar to0.6 mmol/L) ZR, regardless of group. In hearts, monounsaturated (MU) FA were greater and PU FA were proportionally lower in obese compared to thelean rats. In soleus, saturated and MU FA were greater and PU FA were proportionally lower in the obese compared to the lean rats. DHEA groups displayed significantly increased proportions of TL AA and decreased oleic acid in both muscle types. Mechanisms by which DHEA alters TL FA profiles are a reflection of changes occurring within specific lipid fractions such as FFA,phospholipid, and triglyceride. This study provides initial insights into DHEA's lipid altering effects.

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Documento generato il 04/06/20 alle ore 01:45:09