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Titolo:
Possible role of retinoids in hepatitis B virus-associated liver damage
Autore:
Mawson, AR; Steele, TA;
Indirizzi:
Des Moines Univ, Osteopath Med Ctr, Publ Hlth Program, Des Moines, IA 50312 USA Des Moines Univ Des Moines IA USA 50312 Program, Des Moines, IA 50312 USA Des Moines Univ, Osteopath Med Ctr, Dept Microbiol, Des Moines, IA 50312 USA Des Moines Univ Des Moines IA USA 50312 crobiol, Des Moines, IA 50312 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 8, volume: 226, anno: 2001,
pagine: 734 - 739
SICI:
1535-3702(200109)226:8<734:PRORIH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROSING CHOLESTATIC HEPATITIS; HEPATOCELLULAR-CARCINOMA; VITAMIN-A; HYPERVITAMINOSIS-A; RXR-ALPHA; INFECTION; TRANSPLANTATION; LAMIVUDINE; ANTIGEN; DISEASE;
Keywords:
hepatitis B; virus; retinoids; graft; liver;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Mawson, AR Des Moines Univ, Osteopath Med Ctr, Publ Hlth Program, 3200 Grand Ave, DesMoines, IA 50312 USA Des Moines Univ 3200 Grand Ave Des Moines IA USA 50312 0312 USA
Citazione:
A.R. Mawson e T.A. Steele, "Possible role of retinoids in hepatitis B virus-associated liver damage", EXP BIOL ME, 226(8), 2001, pp. 734-739

Abstract

Liver damage following hepatitis B virus (HBV) infection may be due to theaction of retinoids as modulators of viral replication. The reduced rate of survival of liver grafts in patients with HBV infection could also be dueto the continued presence of the virus, stimulated by retinoids in the graft tissue. Subject to obtaining empirical support for this hypothesis, the use of retinoid-blocking agents could be explored to reduce the risk of liver damage in HBV infection and to enhance the survival of liver grafts. Continued use of such agents may need to be used in conjunction with anti-viral modalities such as HBV hyperimmune globulin and lamivudine to prevent recurrent liver damage and to increase the long-term viability of the graft.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:54:06