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Titolo:
The role of thrombospondin-1 in tumor progression
Autore:
Sargiannidou, I; Zhou, J; Tuszynski, GP;
Indirizzi:
Med Coll Penn & Hahnemann Univ, Dept Pathol & Lab Med, Philadelphia, PA 19129 USA Med Coll Penn & Hahnemann Univ Philadelphia PA USA 19129 ia, PA 19129 USA Med Coll Penn & Hahnemann Univ, Dept Surg, Philadelphia, PA 19129 USA Med Coll Penn & Hahnemann Univ Philadelphia PA USA 19129 ia, PA 19129 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 8, volume: 226, anno: 2001,
pagine: 726 - 733
SICI:
1535-3702(200109)226:8<726:TROTIT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; HUMAN BREAST-CARCINOMA; PLASMINOGEN-ACTIVATOR INHIBITOR-1; ENDOTHELIAL-CELL PROLIFERATION; INTEGRIN-ASSOCIATED PROTEIN; HUMAN SQUAMOUS CARCINOMA; ANGIOGENESIS IN-VITRO; HEPARIN-BINDING; PLATELET THROMBOSPONDIN; EXTRACELLULAR-MATRIX;
Keywords:
thrombospondin-1; adhesion; invasion; angiogenesis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Tuszynski, GP Med Coll Penn & Hahnemann Univ, Dept Pathol, MS 435,245 N 15th St, Philadelphia, PA 19102 USA Med Coll Penn & Hahnemann Univ MS 435,245N 15th St Philadelphia PA USA 19102
Citazione:
I. Sargiannidou et al., "The role of thrombospondin-1 in tumor progression", EXP BIOL ME, 226(8), 2001, pp. 726-733

Abstract

The role of thrombospondin-1 (TSP-1) in tumor progression is both complex and controversial. It is clear from the literature that the function of TSP-1 in malignancy depends on the presence of other factors and the level of TSP-1 expression in the tumor tissue. High levels of TSP-1 secreted by tumors, which were engineered to overexpress TSP-1, inhibit tumor growth, whileanti-sense inhibition of TSP-1 production in certain tumors also inhibits growth. Clearly, the presence of other factors in these experimental systems must be important. The role of TSP-1 in angiogenesis also depends on the levels of TSP-1, the presence and level of angiogenic stimulators such as basic fibroblast growth factor (bFGF), and the localization of TSP-1 in the tissue. Matrix-bound TSP-1 promotes capillary tube formation in the rat aorta model of angiogenesis, while TSP-1 inhibits bFGF- induced angiogenesis in the rat cornea model. The inhibitory effect also depends on the proteolytic state of TSP-11 since the amino terminus promotes angiogenesis in the cornea model, while the remaining140-kDa fragment inhibits bFGF-induced angiogenesis. Both the stimulatory and inhibitory effects of TSP-1 are likely due to upregulation of matrix-degrading enzymes and their inhibitors. These enzymes are critical for maintaining optimal matrix turnover during angiogenesis. These varied TSP-1-dependent mechanisms offer new targets for the development of anti-angiogenic therapeutics for the treatment of a variety of cancers, as well as other pathologies involving inappropriate angiogenesis such as diabetic retinopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:11:49