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Titolo:
NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease
Autore:
Crocker, SJ; Wigle, N; Liston, P; Thompson, CS; Lee, CJ; Xu, DG; Roy, S; Nicholson, DW; Park, DS; MacKenzie, A; Korneluk, RG; Robertson, GS;
Indirizzi:
Univ Ottawa, Fac Med, Neurosci Res Inst, Ottawa, ON K1H 8M5, Canada Univ Ottawa Ottawa ON Canada K1H 8M5 Res Inst, Ottawa, ON K1H 8M5, Canada Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada Univ Ottawa Ottawa ON Canada K1H 8M5 Mol Med, Ottawa, ON K1H 8M5, Canada AEgera Inc, Ottawa, ON K1H 8M5, Canada AEgera Inc Ottawa ON Canada K1H 8M5 Egera Inc, Ottawa, ON K1H 8M5, Canada Childrens Hosp Eastern Ontario, Solange Gauthier Karsh Mol Genet Lab, Ottawa, ON K1H 8L1, Canada Childrens Hosp Eastern Ontario Ottawa ON Canada K1H8L1 N K1H 8L1, Canada Merck Frosst Canada Inc, Biochem & Mol Biol, Pointe Claire, PQ H9R 4P8, Canada Merck Frosst Canada Inc Pointe Claire PQ Canada H9R 4P8 Q H9R 4P8, Canada
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 391 - 400
SICI:
0953-816X(200107)14:2<391:NPTNDP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; SUBSTANTIA-NIGRA; NEUROTROPHIC FACTOR; GENE-THERAPY; COMPLEX-I; 6-HYDROXYDOPAMINE-INDUCED DEGENERATION; CASPASE-3-LIKE PROTEASES; NEURONS; APOPTOSIS; INHIBITOR;
Keywords:
axotomy; basal ganglia; caspase-3; NAIP; Parkinson's disease; substantia nigra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Crocker, SJ Univ Ottawa, Fac Med, Neurosci Res Inst, 451 Smyth Rd, Ottawa,ON K1H 8M5,Canada Univ Ottawa 451 Smyth Rd Ottawa ON Canada K1H 8M5 H 8M5,Canada
Citazione:
S.J. Crocker et al., "NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease", EUR J NEURO, 14(2), 2001, pp. 391-400

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder of the basal ganglia, associated with the inappropriate death of dopaminergic neurons of the substantia nigra pars compacta (SNc). Here, we show that adenovirally mediated expression of neuronal apoptosis inhibitor protein (NAIP) ameliorates the loss of nigrostriatal function following intrastriatal 6-OHDA administration by attenuating the death of dopamine neurons and dopaminergic fibres in the striatum. In addition, we also addressed the role of thecysteine protease caspase-3 activity in this adult 6-OHDA model, because arole for caspases has been implicated in the loss of dopamine neurons in PD, and because NAIP is also a reputed inhibitor of caspase-3. Although caspase-3-like proteolysis was induced in the SNc dopamine neurons of juvenile rats lesioned with 6-OHDA and in adult rats following axotomy of the medialforebrain bundle, caspase-3 is not induced in the dopamine neurons of adult 6-OHDA-lesioned animals. Taken together, these results suggest that therapeutic strategies based on NAIP may have potential value for the treatment of PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:15:01