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Titolo:
Exogenous NT-3 and NGF differentially modulate PACAP expression in adult sensory neurons, suggesting distinct roles in injury and inflammation
Autore:
Wallin, HJ; Danielsen, N; Johnston, JM; Gratto, KA; Karchewski, LA; Verge, VMK;
Indirizzi:
Univ Saskatchewan, Saskatoon City Hosp, Dept Anat & Cell Biol, Saskatoon, SK S7K 0M7, Canada Univ Saskatchewan Saskatoon SK Canada S7K 0M7 skatoon, SK S7K 0M7, Canada Univ Saskatchewan, Saskatoon City Hosp, Cameco MS Neurosci Res Ctr, Saskatoon, SK S7K 0M7, Canada Univ Saskatchewan Saskatoon SK Canada S7K 0M7 skatoon, SK S7K 0M7, Canada Lund Univ, Dept Physiol Sci, S-22100 Lund, Sweden Lund Univ Lund Sweden S-22100 iv, Dept Physiol Sci, S-22100 Lund, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 14, anno: 2001,
pagine: 267 - 282
SICI:
0953-816X(200107)14:2<267:ENANDM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING POLYPEPTIDE; NERVE GROWTH-FACTOR; DORSAL-ROOT GANGLIA; CILIARY NEUROTROPHIC FACTOR; VASOACTIVE-INTESTINAL-PEPTIDE; LEUKEMIA INHIBITORY FACTOR; GENE-RELATED PEPTIDE; SCIATIC-NERVE; MESSENGER-RNA; SPINAL-CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Verge, VMK Univ Saskatchewan, Saskatoon City Hosp, Dept Anat & Cell Biol, Room 5800,701 Queen St, Saskatoon, SK S7K 0M7, Canada Univ Saskatchewan Room 5800,701 Queen St Saskatoon SK Canada S7K 0M7
Citazione:
H.J. Wallin et al., "Exogenous NT-3 and NGF differentially modulate PACAP expression in adult sensory neurons, suggesting distinct roles in injury and inflammation", EUR J NEURO, 14(2), 2001, pp. 267-282

Abstract

Expression of pituitary adenylate cyclase-activating polypeptide in sensory neurons varies with injury or inflammation. The neurotrophins NGF and NT-3 are profound regulators of neuronal peptidergic phenotype in intact and injured sensory neurons. This study examined their potential for modulation of PACAP expression in adult rat with intact and injured L4-L6 spinal nerves with or without immediate or delayed intrathecal infusion of NT-3 or NGF. Results indicate that in L5 DRG, few trkC neurons express high levels of PACAP mRNA in the intact state, but many do following injury. The elevated expression in injured neurons is mitigated by NT-3 infusion, suggesting a role for NT-3 in returning the 'injured phenotype' back towards an 'Intact phenotype'. NGF dramatically up-regulated PACAP expression in trkA-positive neurons in both intact and injured DRGs, implicating NGF as a positive regulator of PACAP expression in nociceptive neurons. Surprisingly, NT-3 modulates PACAP expression in an antagonistic fashion to NGF in intact neurons, aneffect most evident in the trkA neurons not expressing trkC. Both NT-3 andNGF infusion results in decreased detection of PACAP protein in the regionof the gracile nuclei, where central axons of the peripherally axotomized large sensory fibers terminate. NGF infusion also greatly increased the amount of PACAP protein detected in the portion of the dorsal horn innervated by small-medium size DRG neurons, while both neurotrophins appear able to prevent the decrease in PACAP expression observed in these afferents with injury. These results provide the first insights into the potential moleculesimplicated in the complex regulation of PACAP expression in sensory neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:12:35