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Titolo:
Molecular features of Co-III tetra- and pentammines affect their influenceon DNA structure
Autore:
Rodger, A; Parkinson, A; Best, S;
Indirizzi:
Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England Univ Warwick Coventry W Midlands England CV4 7AL 7AL, W Midlands, England Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 arkville, Vic 3010, Australia
Titolo Testata:
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
fascicolo: 9, , anno: 2001,
pagine: 2311 - 2316
SICI:
1434-1948(200109):9<2311:MFOCTA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
COBALT-PENTAMMINE; POLYAMINES; TRANSITION; BINDING; CATIONS; HEXAMMINE; SPERMINE;
Keywords:
bioinorganic chemistry; non-covalent interactions; coordination chemistry; circular dichroism; UV/Vis spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Rodger, A Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England Univ Warwick Coventry W Midlands England CV4 7AL lands, England
Citazione:
A. Rodger et al., "Molecular features of Co-III tetra- and pentammines affect their influenceon DNA structure", EUR J INORG, (9), 2001, pp. 2311-2316

Abstract

The polyamines spermine and spermidine cause a range of structural effectson DNA. [Co(NH3)(6)](3+) is known to mimic many of these effects and we have shown previously that (+)[Co(en)(3)](3+) and (-)-[Co(en)(3)](3+) (en = ethylenediamine) do so as well. In this paper the effects of mono- and disubstitution of the Coin ammines by aqua, halo and nitro groups is explored. The overall effectiveness of the amines in conferring thermal stability on the ct-DNA proceeds in the order: spermine > (+)-[Co(en)(3)](3+) approximateto (-)-[Co(en)(3)](3+) approximate to [Co(NH3)(6)](3+) spermidine > [Pt(NH3)(4)](2+) > [Co(NH3)(5)H2O](3+) [Co(NH3)(5)Cl](2+) approximate to [Co(NH3)(5)Br](2+) > cis-[Co(en)(2)NH3Cl](2+) > [Co(NH3)(5)(NO2)](2+) = trans-(Co(NH3)(4)(H2O)(2)](3+); whereas the B -->Z transition-induction ordering is: spermine approximate to [Co(NH3)(6)](3+) > (+)-[Co(en)(3)](3+) = [Co(NH3)(5)(H2O)](3+) > (-)-[Co(en)(3)](3+) > [Co(NH3)(5)Br](2+) > [Co(NH3)(5)Cl](2+),with the other amines failing to cause the transition under the 11 mm saltconcentration and temperature ramp conditions used; the DNA bending ranking is: spermine > [Co(NH3)(6)](3+) > (+)-[Co(en)(3)](3+) > (-)[Co(en)(3)](3+) > [Co(NH3)(5)(H2O)](3+) > trans-[Co(NH3)(4)(H2O)(2)](3+) > spermidine, with the other 2+ amines (the aquo complexes will be 2+ at neutral pH), especially the bromo and nitro compounds, having comparatively little effect. While the presentation of NNN triangular faces is found to be important in the B -->Z transition, the fact that the halo ligands are probably substituted by the DNA phosphates plays a role, especially in the DNA bending, where deep penetration of the major groove is concluded to be required. A favourable interaction between the backbone and the aquo ligands may enhance the B-->Z transition.

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Documento generato il 20/10/20 alle ore 05:51:32