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Titolo:
Abnormal contractile responses during dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy
Autore:
de Jong, RM; Cornel, JH; Crijns, HJGM; van Veldhuisen, DJ;
Indirizzi:
Univ Groningen Hosp, Dept Cardiol, Ctr Thorax, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Med Ctr Alkmaar, Alkmaar, Netherlands Med Ctr Alkmaar Alkmaar Netherlands d Ctr Alkmaar, Alkmaar, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF HEART FAILURE
fascicolo: 4, volume: 3, anno: 2001,
pagine: 429 - 436
SICI:
1388-9842(200108)3:4<429:ACRDDS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; WALL MOTION ABNORMALITIES; LEFT-VENTRICULAR FUNCTION; POSITRON-EMISSION-TOMOGRAPHY; CONGESTIVE-HEART-FAILURE; MYOCARDIAL-ISCHEMIA; NONINVASIVE DIFFERENTIATION; BIPHASIC RESPONSE; DYSFUNCTION; IMPROVEMENT;
Keywords:
idiopathic dilated cardiomyopathy; dobutamine stress echocardiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
R.M. de Jong et al., "Abnormal contractile responses during dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy", EUR J HE FA, 3(4), 2001, pp. 429-436

Abstract

Background: In chronic heart failure augmented wall stress leads to increased energy demand. Supply, however, may be reduced due to coronary vasoconstriction and endothelial dysfunction. This might lead to a mismatch betweendemand and supply. In the present study we further explored the effect of increased demand during dobutamine stress echocardiography. Methods and results: Sixteen patients with idiopathic dilated cardiomyopathy (mean age 44 /- 13 years, New York Heart Association class II-III, mean left ventricular ejection fraction 0.27 +/- 0.10) underwent dobutamine stress echocardiography (5-40 mug/min per kg bodyweight + atropine if required). Wall motion and thickening was assessed in 16 segments using a four-point scale. Eleven patients (69%) showed regions with worsening of wall motion or a biphasic response during dobutamine infusion. Of the remaining five patients one patient did not show any wall motion changes and one patient showed a partial improvement while only in three patients wall motion improvement in the whole heart was found. Conclusion: A majority of patients with idiopathic dilated cardiomyopathy showed decreased wall motion during increased demand, i.e. ischemia-like myocardial contractile responses during dobutamine stress echocardiography. These findings further support the concept that an energy mismatch between demand and supply might play a pathophysiological role in idiopathic dilated cardiomyopathy. (C) 2001 European Society of Cardiology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:16:31