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Titolo:
Breath isoprene in patients with heart failure
Autore:
McGrath, LT; Patrick, R; Silke, B;
Indirizzi:
Queens Univ Belfast, Dept Therapeut & Pharmacol, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT9 7BL m, North Ireland Queens Univ Belfast, Dept Chem, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT9 7BL m, North Ireland
Titolo Testata:
EUROPEAN JOURNAL OF HEART FAILURE
fascicolo: 4, volume: 3, anno: 2001,
pagine: 423 - 427
SICI:
1388-9842(200108)3:4<423:BIIPWH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; OXYGEN-FREE-RADICALS; LIPID-PEROXIDATION; MASS-SPECTROMETRY; PENTANE; HYDROCARBONS; CHOLESTEROL; EXCRETION; ENDOTOXIN; OUTPUT;
Keywords:
heart failure; isoprene; breath; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: McGrath, LT Queens Univ Belfast, Dept Therapeut & Pharmacol, 97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast 97 Lisburn Rd Belfast Antrim North Ireland BT9 7BL
Citazione:
L.T. McGrath et al., "Breath isoprene in patients with heart failure", EUR J HE FA, 3(4), 2001, pp. 423-427

Abstract

Background: Chronic heart failure (CHF) is characterised by increased vascular resistance. This increased after load on the left ventricle contributes to the vicious cycle that leads to progression of myocardial failure, multiple organ failure and death. There is evidence for increased oxidative stress in heart failure, which will influence the myocardium but also peripheral vasculature endothelium. Aims: The aim of the present study was to examine the production of isoprene, reputed to reflect oxidative stress, in patients with CHF compared to control subjects. Methods: Twelve patients with CHF and thirty-one healthy control subjects free from heart disease were studied. Breath was collected via a two-way non-re-breathing valve into a 60-1 gas collection bag. A sample of ambient air was collected at the same time. A measured aliquot of patient breath and ambient air (approx. 1.5 l) wasadsorbed onto a gas adsorption tube packed with poropak-Q. Isoprene was measured using GC/MS and the production rate calculated. All samples of breath were collected at 10.00 It after subjects had been sitting at rest for 15min. Results: Breath isoprene production in subjects with CHF was significantly reduced compared to controls 83(23) vs. 168(20) pmol min(-1) kg(-1). Conclusion: Breath isoprene does not directly reflect oxidative stress in CHF. (C) 2001 European Society of Cardiology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:33:49