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Titolo:
Activation of the cardiac interleukin-6 system in advanced heart failure
Autore:
Plenz, G; Song, ZF; Tjan, TDT; Koenig, C; Baba, HA; Erren, M; Flesch, M; Wichter, T; Scheld, HH; Deng, MC;
Indirizzi:
Univ Munster, Dept Cardiothorac Surg, D-48129 Munenster, Germany Univ Munster Munenster Germany D-48129 Surg, D-48129 Munenster, Germany Univ Munster, Dept Cardiol & Angiol, D-48129 Munenster, Germany Univ Munster Munenster Germany D-48129 ngiol, D-48129 Munenster, Germany Univ Munster, Inst Arteriosclerosis Res, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 rosis Res, D-48149 Munster, Germany Univ Munster, Gerhard Domagk Inst Pathol, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 st Pathol, D-48149 Munster, Germany Univ Munster, Inst Clin Chem & Lab Med, D-48129 Munenster, Germany Univ Munster Munenster Germany D-48129 b Med, D-48129 Munenster, Germany Univ Cologne, Dept Internal Med Cardiol, Cologne, Germany Univ Cologne Cologne Germany ept Internal Med Cardiol, Cologne, Germany Muenster Univ, Transplant Ctr, Munster, Germany Muenster Univ Munster Germany er Univ, Transplant Ctr, Munster, Germany Columbia Univ Coll Phys & Surg, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
EUROPEAN JOURNAL OF HEART FAILURE
fascicolo: 4, volume: 3, anno: 2001,
pagine: 415 - 421
SICI:
1388-9842(200108)3:4<415:AOTCIS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; IDIOPATHIC DILATED CARDIOMYOPATHY; LEFT-VENTRICULAR DYSFUNCTION; PROINFLAMMATORY CYTOKINES; NITRIC-OXIDE; FACTOR-ALPHA; MESSENGER-RNA; GP130; MYOCARDIUM; TRANSPLANTATION;
Keywords:
interleukin-6; heart failure; cardiomyopathy; hemodynamics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Plenz, G Univ Munster, Dept Cardiothorac Surg, Albert Schweitzer Str 33, D-48129 Munenster, Germany Univ Munster Albert Schweitzer Str 33 Munenster Germany D-48129
Citazione:
G. Plenz et al., "Activation of the cardiac interleukin-6 system in advanced heart failure", EUR J HE FA, 3(4), 2001, pp. 415-421

Abstract

Objectives: The study objective was to assess the cardiac expression of interleukin-6 (IL6) and its receptor (IL6R) in advanced heart failure. Background: While IL6 plasma levels are elevated and associated with an impaired prognosis in advanced heart failure, little is known about the intracardiacexpression of the IL6 system. Methods: Heart tissue was obtained from 20 patients (n = 10, idiopathic dilated cardiomyopathy, age 44 +/- 15 years; n = 10, ischemic cardiomyopathy, age 55 +/- 8 years) at the time of transplantation. Left and right ventricular tissue was subjected to in situ hybridization, Northern blot analysis, and RT-PCR. Signals were quantified by densitometric scanning and corrected for G3PDH-mRNA levels. Right ventricular biopsy specimens (n = 11) of patients with arrhythmias and normal cardiac function served as controls. In addition, data were correlated with cardiac catheterization and echocardiography data obtained at transplant evaluation. Results: Ventricular IL6 and IL6R transcripts were detected in all explant specimens examined. Expression of both mRNA species was higher than in controls (P = 0.001). Left ventricular IL6 mRNA levels correlated positively with heart rate (r = 0.77; P = 0.009), pulmonary capillary wedge pressure (r = 0.53; P = 0.03), right atrial pressure (r 0.77; P = 0.003), and inverselywith left ventricular ejection fraction (r = -0.61; P = 0.03). Right ventricular IL6 mRNA levels correlated inversely with cardiac index (r = -0.48; P = 0.05). IL6R expression did not correlate with hemodynamic data. Conclusions: In advanced heart failure, cardiac IL6/IL6R mRNA expression is increased and may play a role in the pathophysiology of advanced heart failure. (C) 2001 European Society of Cardiology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:49:28