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Titolo:
Determination of pharmacokinetic parameters of stavudine in Japanese patients infected with HIV-1, using a Gaussian-like input rate function
Autore:
Tatsunami, S; Ito, A; Kawata, K; Kuwabara, R; Yamada, K;
Indirizzi:
St Marianna Univ, Sch Med, Radioisotope Res Inst, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan St Marianna Univ Kawasaki Kanagawa Japan 2168511 Kanagawa 2168511, Japan Yokohama City Univ Med, Sch Med, Div Clin Lab Med, Yokohama, Kanagawa, Japan Yokohama City Univ Med Yokohama Kanagawa Japan Yokohama, Kanagawa, Japan St Marianna Univ, Sch Med, Inst Med Sci, Kawasaki, Kanagawa, Japan St Marianna Univ Kawasaki Kanagawa Japan Sci, Kawasaki, Kanagawa, Japan
Titolo Testata:
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
fascicolo: 1-2, volume: 26, anno: 2001,
pagine: 137 - 140
SICI:
0378-7966(200101/06)26:1-2<137:DOPPOS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIDANOSINE;
Keywords:
stavudine; compartment model; hemophilia; HIV-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Tatsunami, S St Marianna Univ, Sch Med, Radioisotope Res Inst, Miyamae Ku,2-16-1 Sugao, Kawasaki, Kanagawa 2168511, Japan St Marianna Univ 2-16-1 Sugao Kawasaki Kanagawa Japan 2168511
Citazione:
S. Tatsunami et al., "Determination of pharmacokinetic parameters of stavudine in Japanese patients infected with HIV-1, using a Gaussian-like input rate function", EUR J DRUG, 26(1-2), 2001, pp. 137-140

Abstract

We sought to examine variation in pharmacokinetic parameters of stavudine in Japanese patients' infected with HIV-1. Stavudine concentrations were measured in two hemophiliacs (HIV-1 asymptomatic carriers (ACs)) and two non-hemophiliacs (both ACs). To simulate the plasma stavudine concentrations following a single oral dose, we used a Gaussian-like input rate function in a single compartment model. The theoretical equation successfully simulatedchanges in the time course of plasma stavudine concentrations in all four patients. The mean +/- SD of T-max, C-max, AUC(0-infinity), and t(1/2) were0.96 +/-0.26 hr, 478 +/- 90 ng/mL, 1112 +/- 136 ng.hr/mL, and 1.26 +/-0.23hr, respectively. Pharmacokinetic characteristics were comparable to thosereported in the literature, although the mean of C-max was slightly lower and means of T-max and t(1/2) slightly longer than those previously reported. Interpatient variability in plasma stavudine concentrations was not as dramatic as that seen with lamivudine. Thus, we confirmed the validity of the uniform therapeutic regimen of stavudine in Japanese people with HIV-1 infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:00:35