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Titolo:
Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy
Autore:
Stephen, LJ; Kwan, P; Shapiro, D; Dominiczak, M; Brodie, MJ;
Indirizzi:
Univ Glasgow, Western Infirm, Dept Med & Therapeut, Epilepsy Unit, GlasgowG11 6NT, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G11 6NT gowG11 6NT, Lanark, Scotland Gartnavel Royal Hosp, Dept Pathol Biochem, Glasgow, Lanark, Scotland Gartnavel Royal Hosp Glasgow Lanark Scotland , Glasgow, Lanark, Scotland
Titolo Testata:
EPILEPSIA
fascicolo: 8, volume: 42, anno: 2001,
pagine: 1002 - 1006
SICI:
0013-9580(200108)42:8<1002:HPIYAW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC OVARIAN SYNDROME; RECEIVING ANTICONVULSANT MEDICATION; INSULIN-RESISTANCE; ENDOCRINE DISORDERS; WEIGHT-GAIN; WOMEN; HYPERANDROGENISM; PATHOGENESIS; METABOLISM; OBESITY;
Keywords:
sodium valproate; lamotrigine; insulin; testosterone; lipids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Brodie, MJ Univ Glasgow, Western Infirm, Dept Med & Therapeut, Epilepsy Unit, GlasgowG11 6NT, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G11 6NT Lanark, Scotland
Citazione:
L.J. Stephen et al., "Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy", EPILEPSIA, 42(8), 2001, pp. 1002-1006

Abstract

Purpose: Treatment with sodium valproate (VPA) may be associated with polycystic ovarian syndrome (PCOS) in some women with epilepsy. By comparing hormone profiles in young adults taking VPA or lamotrigine (LTG) as monotherapy, this study aimed to explore whether a pharmacologic effect of VPA Couldbe responsible for this observation. Methods: Hormone profiles in men and women taking VPA (n = 40) or LTG (n =36) monotherapy for epilepsy were compared. None of the women were receiving hormonal contraception or replacement. Patients gave details of seizure type and frequency, menstrual cycle. and medical and drug history. Body mass index was calculated. and fasting insulin, glucose, cholesterol. triglycerides (TG). high- and low-density lipoproteins, testosterone, dihydroepiandosterone (DHEA). androstenedione. sex hormone-binding globulin (SHBG), freeandrogen index (FAI), luteinising hormone (LH), follicle-stimulating hormone (FSH), and antiepileptic drug (AED) concentrations were measured. Results: There were no differences between treatment groups for both sexesin age and seizure control. Only four obese VPA-treated women were hyperinsulinaemic (p = 0.05) three with abnormal menstrual cycles. one with raisedtestosterone. Testosterone (p = 0.02), FAI (p = 0.03). and TG (p = 0.02) levels were higher, however. in women taking the drug. Obese patients of both sexes (p = 0.01) and VPA-treated men (p = 0.03) had higher insulin concentrations. Conclusions: VPA therapy may be associated with subclinical elevation in fasting insulin levels. Testosterone and TG levels were higher in VPA-treated women compared with the levels in those taking LTG. However only a minority of obese females exhibited biochemical characteristics suggestive of PCOS. Biochemical screening may allow women at risk of developing PCOS to avoid VPA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:19:19