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Titolo:
Polycystic ovarian syndrome in women with epilepsy: A review
Autore:
Duncan, S;
Indirizzi:
Hope Hosp, Clin Neurosci Ctr, Manchester, Lancs, England Hope Hosp Manchester Lancs England rosci Ctr, Manchester, Lancs, England
Titolo Testata:
EPILEPSIA
, volume: 42, anno: 2001, supplemento:, 3
pagine: 60 - 65
SICI:
0013-9580(2001)42:<60:POSIWW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRODUCTIVE ENDOCRINE DISORDERS; GONADOTROPIN-RELEASING-HORMONE; TEMPORAL-LOBE EPILEPSY; MALE PATTERN BALDNESS; INSULIN-RESISTANCE; PARTIAL SEIZURES; SERUM PROLACTIN; VALPROATE; PREVALENCE; POPULATION;
Keywords:
polycystic ovarian syndrome; polycystic ovary morphology; epilepsy; antiepileptic drugs; menstruation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Duncan, S Hope Hosp, Clin Neurosci Ctr, Manchester, Lancs, England Hope Hosp Manchester Lancs England Manchester, Lancs, England
Citazione:
S. Duncan, "Polycystic ovarian syndrome in women with epilepsy: A review", EPILEPSIA, 42, 2001, pp. 60-65

Abstract

Polycystic ovarian syndrome (PCOS) remains a controversial issue in women with epilepsy. The syndrome is characterized by clinical signs of endocrinedysfunction, such as irregular menstruation, hirsutism, and infertility, but its pathogenesis and presentation are heterogeneous. There are few data on the relationship between epilepsy and PCOS. Studies by a Finnish group have raised the issue of an association between valproate (VPA) and PCOS in young women with epilepsy. These studies, however, were retrospective, laidemphasis on polycystic ovary morphology rather than on clinical endocrine dysfunction, and were undertaken in selected populations. Further studies, both in Italy and Germany, failed to replicate the findings of the Finnish group. Future research should ideally be prospective and include baseline data in untreated women. No compelling data lead to a specific contraindication of the use of VPA in young women, and the drug remains a first-line treatment option.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:38:54