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Titolo:
Lung C-fiber CNS reflex: Role in the respiratory consequences of extended environmental tobacco smoke exposure in young guinea pigs
Autore:
Bonham, AC; Chen, CY; Mutoh, T; Joad, JP;
Indirizzi:
Univ Calif Davis, Div Cardiovasc Med, Dept Internal Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 ept Internal Med, Davis, CA 95616 USA Univ Calif Davis, Dept Pharmacol, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 , Dept Pharmacol, Davis, CA 95616 USA Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA Univ Calif Davis DavisCA USA 95616 vis, Dept Pediat, Davis, CA 95616 USA Kobe Univ, Sch Med, Dept Anat & Brain Sci, Kobe, Hyogo 650, Japan Kobe Univ Kobe Hyogo Japan 650 t Anat & Brain Sci, Kobe, Hyogo 650, Japan
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
, volume: 109, anno: 2001, supplemento:, 4
pagine: 573 - 578
SICI:
0091-6765(200108)109:<573:LCCRRI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOREACTIVE NERVE-TERMINALS; NUCLEUS TRACTUS SOLITARIUS; SUBSTANCE-P RECEPTORS; CIGARETTE-SMOKE; PARENTAL SMOKING; MATERNAL SMOKING; CHILDHOOD ASTHMA; SENSORY NERVES; VAGAL; AFFERENTS;
Keywords:
CNS; environmental tobacco smoke; lung C fibers; neuroplasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Bonham, AC Univ Calif Davis, Div Cardiovasc Med, Dept Internal Med, TB 1721 Shields Ave, Davis, CA 95616 USA Univ Calif Davis TB 172 1 Shields Ave Davis CA USA 95616 16 USA
Citazione:
A.C. Bonham et al., "Lung C-fiber CNS reflex: Role in the respiratory consequences of extended environmental tobacco smoke exposure in young guinea pigs", ENVIR H PER, 109, 2001, pp. 573-578

Abstract

Environmental tobacco smoke (ETS) exposure harms the respiratory health ofchildren and is associated with an increased risk of asthma and sudden infant death syndrome (SIDS). The mechanisms by which ETS causes these effectsare not understood. We hypothesized that one mechanism is an upregulation of the lung C-fiber central nervous system (CNS) reflex responses, which would result in exaggerated reflex responses of apnea, bronchoconstriction, and mucous hypersecretion. The purpose of this work is to highlight evidenceobtained in an animal model of postnatal ETS exposure supporting the hypothesis and present data suggesting that actions of the neuropeptide substance P in the nucleus tractus solitarius (NTS) may contribute. Exposing young guinea pigs to sidestream smoke, the surrogate for ETS, for 5 weeks during the equivalent of human childhood, increased the excitability of afferent lung C fibers and NTS neurons in the CNS reflex pathway and prolonged the expiratory apnea. The findings suggest that an increased excitability of NTS neurons that can augment reflex output may contribute to respiratory symptoms in children exposed to ETS. Besides ETS exposure, substance P can also excite NTS neurons and augment lung C-fiber CNS reflex responses. Others have shown that substance P synthesis in lung C fibers is upregulated by another environmental stimulant, allergen. Thus, an upregulation of the substance P system at NTS synapses could contribute to the increased NTS excitability and enhanced reflex responses to lung C-fiber stimulation, providing a potential mechanism to help explain the association of ETS exposure with respiratory symptoms and SIDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:51:24