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Titolo:
Peptides derived from pro-growth hormone-releasing hormone activate p38 mitogen-activated protein kinase in GH3 pituitary cells
Autore:
Steinmetz, R; Zeng, PY; King, DW; Walvoord, E; Pescovitz, OH;
Indirizzi:
James Whitcomb Riley Hosp Children, Indianapolis, IN 46202 USA James Whitcomb Riley Hosp Children Indianapolis IN USA 46202 IN 46202 USA Indiana Univ, Sch Med, Dept Pediat Physiol & Biophys, Wells Ctr Pediat Res,Sect Pediat Endocrinol Diabe, Indianapolis, IN 46204 USA Indiana Univ Indianapolis IN USA 46204 Diabe, Indianapolis, IN 46204 USA
Titolo Testata:
ENDOCRINE
fascicolo: 1, volume: 15, anno: 2001,
pagine: 119 - 127
SICI:
1355-008X(200106)15:1<119:PDFPHH>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERNARY COMPLEX FACTORS; ETS TRANSCRIPTION FACTOR; ELEMENT-BINDING PROTEIN; SERUM RESPONSE ELEMENT; MAP KINASE; DIFFERENTIAL EXPRESSION; FACTOR P62TCF; SERTOLI-CELL; C-KIT; PHOSPHORYLATION;
Keywords:
GHRH; MAPK; GH(3) cells; growth hormone-releasing hormone related peptide; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Steinmetz, R James Whitcomb Riley Hosp Children, 702 Barnhill Dr,Room A5984, Indianapolis, IN 46202 USA James Whitcomb Riley Hosp Children 702 Barnhill Dr,Room A5984 Indianapolis IN USA 46202
Citazione:
R. Steinmetz et al., "Peptides derived from pro-growth hormone-releasing hormone activate p38 mitogen-activated protein kinase in GH3 pituitary cells", ENDOCRINE, 15(1), 2001, pp. 119-127

Abstract

Posttranslational processing of the pro-growth hormone-releasing hormone (proGHRH) peptide can result in the formation of at least two peptide products: GHRH and the C-terminal peptide, GHRH-related peptide (GHRH-RP). While cyclic adenosine monophosphate transduces many of the actions of GHRH, other pathways also have been implicated in its actions. The aims of this studywere to examine and characterize the activation of mitogen-activated protein kinase (MAPK) pathways by GHRH, and GHRH-RP in pituitary-derived GH3 cells, as well as the activation of the transcription factors that serve as substrates for these kinases. GHRH rapidly increased p44/p42 MAPK activity inGH3 cells in a protein kinase A-dependent and a protein kinase C-independent manner and stimulated the activation of the transcription factor Elk-1. By contrast, GHRH-RP and p75-92NH2 had no effect on p44/p42 MAPK phosphorylation in these cells. Additionally, we determined that all three peptides, GHRH, GHRH-RP, and p75-92NH2, rapidly and specifically increase phosphorylation of p38 MAPK and stimulate the activation of the nuclear factor CHOP. These are the first studies to demonstrate the activation of Elk-1 by GHRH and the activation of p38 MAPK and CHOP by GHRH, GHRH-RP, and p75-92NH2. We conclude that members of the GHRH family of peptides differentially activate multiple intracellular signaling pathways and suggest that the biologic actions of GHRH may be far more diverse than previously thought.

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Documento generato il 11/07/20 alle ore 04:39:55