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Titolo:
Cold-induced increment in rat adrenal gland type II deiodinase is corticosterone dependent
Autore:
Anguiano, B; Valverde-R, C;
Indirizzi:
Univ Nacl Autonoma Mexico, Ctr Neurobiol, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico
Titolo Testata:
ENDOCRINE
fascicolo: 1, volume: 15, anno: 2001,
pagine: 87 - 91
SICI:
1355-008X(200106)15:1<87:CIIRAG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROENDOCRINE REGULATION; 5'DEIODINASE ACTIVITY; GLUCOCORTICOIDS; HYPOPHYSECTOMY; STRESS; BRAIN;
Keywords:
type II deiodinase activity; adrenal gland; corticosterone; cold stress; aminoglutethimide; metyrapone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Valverde-R, C Univ Nacl Autonoma Mexico, Ctr Neurobiol, Campus UNAM-UAQ Juriquilla 76001,Queretera Qro Ap, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Campus UNAM-UAQ Juriquilla 76001,Queretera Qro Ap Mexico CityDF Mexico 04510
Citazione:
B. Anguiano e C. Valverde-R, "Cold-induced increment in rat adrenal gland type II deiodinase is corticosterone dependent", ENDOCRINE, 15(1), 2001, pp. 87-91

Abstract

in this study we analyzed whether corticosterone synthesis is involved in the regulation of adrenal gland type if deiodinase (AG-D2) activity during acute cold exposure. Two well-known inhibitors of steroidogenesis, aminoglutethimide (AGT) and metyrapone (MTP), were administered to male Wistar ratsmaintained either at room temperature or acutely exposed to cold (1 h at 4degreesC). AG-D2 activity was measured by the radioiodide release method, and corticosterone circulating levels were measured by competitive protein binding assay. Results show that resting corticosterone levels and AG-D2 activity were lower in both AGT- and MTP-treated rats. Furthermore, the phasic increase normally exhibited by AG-D2 activity in response to acute cold stress was blunted in AGT- and MTP-treated animals. Therefore, we conclude that corticosterone synthesis is necessary in preserving the physiologic response of AG-D2 activity to cold exposure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:37:40