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Titolo:
Nongenomic action of steroids in myometrial contractility
Autore:
Perusquia, M;
Indirizzi:
Natl Autonomous Univ Mexico, Biomed Res Inst, Mexico City 04510, DF, Mexico Natl Autonomous Univ Mexico Mexico City DF Mexico 04510 04510, DF, Mexico Oregon Reg Primate Res Ctr, Div Reprod Sci, Beaverton, OR 97006 USA OregonReg Primate Res Ctr Beaverton OR USA 97006 Beaverton, OR 97006 USA
Titolo Testata:
ENDOCRINE
fascicolo: 1, volume: 15, anno: 2001,
pagine: 63 - 72
SICI:
1355-008X(200106)15:1<63:NAOSIM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
UTERINE BLOOD-FLOW; SMOOTH-MUSCLE; RAT UTERUS; SEX STEROIDS; IN-VITRO; PROGESTERONE METABOLITES; 4-HYDROXYLATED ESTRADIOL; CORONARY-ARTERIES; INHIBITORY-ACTION; OVARIAN-STEROIDS;
Keywords:
steroids; nongenomic effects; progesterone metabolites; 5-reduced metabolites; myometrium; uterine relaxation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
137
Recensione:
Indirizzi per estratti:
Indirizzo: Perusquia, M Apartado Postal 70-492, Mexico City 04511, DF, Mexico Apartado Postal 70-492 Mexico City DF Mexico 04511 F, Mexico
Citazione:
M. Perusquia, "Nongenomic action of steroids in myometrial contractility", ENDOCRINE, 15(1), 2001, pp. 63-72

Abstract

Steroid hormones are involved in several fundamental aspects of all livingbeings, with a few slight chemical differences among steroids being enoughto give them the extraordinarily diverse biologic specificities that are important in animal physiology and medical therapeutics. Indeed, in the uterus, they have a remarkable action on uterine contractility with physiologicsignificance in the important reproductive processes of mammalian pregnancy and parturition. The regulation of progesterone on the myometrial contractile activity and related wider subjects of the endocrinology of pregnancy and parturition have been reviewed many times during the twentieth century. However, new data indicate that several progesterone metabolites and some synthetic steroids induce a progesterone-like uterine-relaxing effect. Experimental evidence from our laboratory has shown that 5-reduced progestins and androgens are more potent than progesterone itself in decreasing uterinecontractility. The purpose of this review is to update current knowledge of endogenous and exogenous steroids on the phenomenon of uterine contractility, by summarizing their structural differences to induce changes on this process and discussing the possible mechanism of steroids to regulate uterine muscle activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:06:09