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Titolo:
Rapid determination of HLA B*07 ligands from the West Nile Virus NY99 genome
Autore:
De Groot, AS; Saint-Aubin, C; Bosma, A; Sbai, H; Rayner, J; Martin, W;
Indirizzi:
Brown Univ, TB HIV Res Lab, Providence, RI 02906 USA Brown Univ Providence RI USA 02906 HIV Res Lab, Providence, RI 02906 USA EpiVax Inc, Providence, RI USA EpiVax Inc Providence RI USAEpiVax Inc, Providence, RI USA
Titolo Testata:
EMERGING INFECTIOUS DISEASES
fascicolo: 4, volume: 7, anno: 2001,
pagine: 706 - 713
SICI:
1080-6040(200107/08)7:4<706:RDOHBL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTE; JAPANESE ENCEPHALITIS-VIRUS; VIRAL-INFECTION; CELL CLONES; LANGERHANS CELLS; IMMUNE-RESPONSE; IN-VIVO; FLAVIVIRUS; ANTIGEN; EPITOPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: De Groot, AS Brown Univ, TB HIV Res Lab, Providence, RI 02906 USA Brown Univ Providence RI USA 02906 Providence, RI 02906 USA
Citazione:
A.S. De Groot et al., "Rapid determination of HLA B*07 ligands from the West Nile Virus NY99 genome", EM INFECT D, 7(4), 2001, pp. 706-713

Abstract

Defined T-cell epitopes for West Nile (WN) virus may be useful for developing subunit vaccines against WN virus infection and diagnostic reagents to detect WN virus-specific immune response. We applied a bioinformatics (EpiMatrix) approach to search the WN virus NY99 genome for HLA B*07 restricted cytotoxic T-cell (CTL) epitopes. Ninety-five of 3,433 WN virus peptides scored above a predetermined cutoff, suggesting that these would be likely to bind to HLA B*07 and would also be likely candidate CTL epitopes. Compared with other methods for genome mapping, derivation of these ligands was rapid and inexpensive. Major histocompatibility complex ligands identified by this method may be used to screen T cells from WN virus-exposed persons for cell-mediated response to WN virus or to develop diagnostic reagents for immunopathogenesis studies and epidemiologic surveillance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:29:30