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Titolo:
Comparison of ThinPrep and TriPath PREP liquid-based preparations in nongynecologic specimens: A pilot study
Autore:
Michael, CW; McConnel, J; Pecott, J; Afify, AM; Al-Khafaji, B;
Indirizzi:
Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA
Titolo Testata:
DIAGNOSTIC CYTOPATHOLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 177 - 184
SICI:
8755-1039(200109)25:3<177:COTATP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FINE-NEEDLE ASPIRATION; PROCESSOR; LAYER; SLIDES;
Keywords:
thin layer; monolayer; cytologic artifacts; ThinPrep; TriPath PREP; AutoCyte PREP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Michael, CW Univ Michigan, Dept Pathol, 1500 E Med Ctr Dr,Room 2G332,Box 0054, Ann Arbor, MI 48109 USA Univ Michigan 1500 E Med Ctr Dr,Room 2G332,Box0054 Ann Arbor MI USA 48109
Citazione:
C.W. Michael et al., "Comparison of ThinPrep and TriPath PREP liquid-based preparations in nongynecologic specimens: A pilot study", DIAGN CYTOP, 25(3), 2001, pp. 177-184

Abstract

ThinPrep (TP) and TriPath PREP (TriP) are two liquid-based cytologic preparations that produce a thin layer of cells. This study compares the diagnostic accuracy and different cytomorphologic alterations produced by these preparations in nongynecologic specimens. Samples from 10 urines (3 urothelial carcinomas and 7 negative), 4 positive serous fluids, and 7 fine-needle aspirates (FNAs) were prepared by both techniques. FNAs represented one eachof: Hashimoto's thyroiditis (HT), hyperplastic colloid nodule (HCN), Hodgkin's lymphoma, liposarcoma, chondrosarcoma, squamous-cell carcinoma (SCC) metastatic to the lymph node, and carcinoid tumor. All 5 participants, none of whom had prior knowledge of the clinical history or histologic diagnosis, reviewed and interpreted the slides. Both techniques produced a clean background and were equally accurate in urines, serous fluids, and three FNAs. TriP was slightly more accurate in four FNAs: HCN and HT where colloid and lymphocytes were better represented, SCC where keratin and malignant cells were more readily identified among lymphocytes, and carcinoid which was easier to evaluate on TriP due to less cellular shrinkage and more dispersion of cells between aggregates. TP preparations had more cell shrinkage, and the chromatin was harder to evaluate. Both techniques produced artificial aggregations of lymphocytes, but TriP had a more evenly dispersed single-cell population between aggregates, rendering them easier to evaluate for atypia. TP produced fragmentation of largesheets that were flattened, while TriP contained larger branching sheets in a three-dimensional (3-D) configuration. TP produced a true monolayer of cells that were all spread at the same plane, while in Trip the cells were spread at slightly different planes, requiring frequent focusing of the viewed plane. While both techniques are acceptable for diagnostic purposes, they both introduce new cytomorphologic alterations that pathologists need to recognize. Trip seems superior to TP in FNAs specimens where preservation of architecture and cellular integrity are important considerations. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:42:04